Results 81 to 90 of about 254,610 (274)

Autoencoders as Weight Initialization of Deep Classification Networks for Cancer versus Cancer Studies [PDF]

arXiv, 2020
Cancer is still one of the most devastating diseases of our time. One way of automatically classifying tumor samples is by analyzing its derived molecular information (i.e., its genes expression signatures). In this work, we aim to distinguish three different types of cancer: thyroid, skin, and stomach.
arxiv  

Enhancer Profiling Reveals a Protective Role of RXRα Against Calcium Oxalate‐Induced Crystal Deposition and Kidney Injury

Advanced Science, EarlyView.
Comprehensive epigenomic and transcriptomic profiling revealed a dynamic enhancer landscape and gene expression program associated with nephrolithiasis, highlighting RXRα as a central transcription factor in this regulatory network. Tubular‐specific deletion of RXRα increased intrarenal CaOx crystal deposition, while its activation with Bexarotene ...
Yu Yang, Xudan Dou, Yongzhan Sun, Mengyao Wang, Jing Wang, Xinyi Cao, Haijie Xie, Linguo Xie, Weiping Tian, Jing Nie, Yupeng Chen, Chunyu Liu, Lirong Zhang   +12 more
wiley   +1 more source

Risk of subsequent primary lymphoma in a cohort of 69,460 five‐year survivors of childhood and adolescent cancer in Europe: The PanCareSurFup study

Cancer, Volume 129, Issue 3, Page 426-440, 1 February 2023., 2023
Abstract Background Survivors of Hodgkin lymphoma (HL) are at risk of developing non‐Hodgkin lymphoma (NHL) after treatment; however, the risks of developing subsequent primary lymphomas (SPLs), including HL and NHL, after different types of childhood cancer are unknown.
Isabelle M. Dudley, Ceren Sunguc, Emma J. Heymer, David L. Winter, Jop C. Teepen, Fabiën N. Belle, Edit Bárdi, Francesca Bagnasco, Thorgerdur Gudmundsdottir, Roderick Skinner, Gisela Michel, Julianne Byrne, Hilde Øfstaas, Momcilo Jankovic, Maja Česen Mazić, Luzius Mader, Jaqueline Loonen, Stanislaw Garwicz, Thomas Wiebe, Daniela Alessi, Rodrigue S. Allodji, Nadia Haddy, Desiree Grabow, Peter Kaatsch, Melanie Kaiser, Milena M. Maule, Zsuzsanna Jakab, Maria Winther Gunnes, Monica Terenziani, Lorna Zadravec Zaletel, Claudia E. Kuehni, Riccardo Haupt, Florent de Vathaire, Leontien C. Kremer, Päivi M. Lähteenmäki, Jeanette F. Winther, Lars Hjorth, Michael M. Hawkins, Raoul C. Reulen   +38 more
wiley   +1 more source

Microfluidics‐Based Microcarriers for Live‐Cell Delivery

Advanced Science, EarlyView.
In this review, recent advancements in microfluidics‐based microcarriers for live‐cell delivery are highlighted. The structural designs of microfluidic‐derived cell‐laden microcarriers are systematically categorized, emphasizing innovative approaches in the fabrication of microspheres, microfibers, and microneedles.
Zhonglin Fang, Xinyuan Yang, Chong Wang, Luoran Shang   +3 more
wiley   +1 more source

Determining the optimal port placement for transoral endoscopic thyroidectomy vestibular approach in a retrospective study

Scientific Reports
With the increasing popularity of minimally invasive techniques in thyroid surgery, the transoral endoscopic thyroidectomy vestibular approach (TOETVA) has garnered significant attention.
Zhizhou Deng, Xiongqiang Hu, Fangang Zeng, Yujun Guo, Xiaowei Peng   +4 more
doaj   +1 more source

Clinical behavior and outcome of papillary T1 thyroid cancers: South Korea vs. Turkey vs. Colombia in a cohort study analyzing oncological outcomes

Asian Journal of Surgery, 2020
Background/Purpose: There has not been an international multicentric study to examine the relationship between thyroid cancer clinical outcomes and geographic location for South Korea, Colombia, and Turkey, whereas thyroid cancer is amongst the highest ...
Murat Ozdemir, Yong-Sang Lee, Ozer Makay, Juan Pablo Dueñas, Bulent Yazici, Aysegul Akgun, Gokhan Icoz, Mahir Akyildiz, Soo Young Kim, Seok-Mo Kim, Hojin Chang, Hang-Seok Chang, Cheong Soo Park   +12 more
doaj  

High Sugar Induced RCC2 Lactylation Drives Breast Cancer Tumorigenicity Through Upregulating MAD2L1

Advanced Science, EarlyView.
This study finds that KAT2A mediates the lactylation modification of the non‐histone protein RCC2 at K124, facilitating the recruitment of free SERBP1 and aiding in the formation of the initial SERBP1‐MAD2L1 complex. SERBP1 enhances the stability of MAD2L1 mRNA and promotes cellular proliferation.
Bowen Zheng, Yunhao Pan, Fengyuan Qian, Diya Liu, Danrong Ye, Bolin Yu, Seng Zhong, Wenfang Zheng, Xuehui Wang, Baian Zhou, Yuying Wang, Lin Fang   +11 more
wiley   +1 more source

Dental management before radiotherapy of the head and neck region: 4‐year single‐center experience

Clinical and Experimental Dental Research, Volume 8, Issue 6, Page 1478-1486, December 2022., 2022
Abstract Objective To review our experience with a standardized dental management approach in patients with planned radiotherapy of the head and neck region based on preradiation and follow‐up data. Material and Methods Records of patients who underwent radiotherapy between June 2016 and November 2020 were reviewed.
Lea Hoffmann, Sebastian N. Marschner, Tamara K. Kakoschke, Reinhard Hickel, Hisham Sabbagh, Uta C. Wölfle   +5 more
wiley   +1 more source

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

Advanced Science, EarlyView.
LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng, Siqi Liu, Jun Wan, Yao Xu, Menglong Wang   +7 more
wiley   +1 more source

The basics of commonly used molecular techniques for diagnosis, and application of molecular testing in cytology

Diagnostic Cytopathology, Volume 51, Issue 1, Page 83-94, January 2023., 2023
Abstract Molecular diagnostics has expanded to become the standard of care for a variety of solid tumor types. With limited diagnostic material, it is often desirable to use cytological preparations to provide rapid and accurate molecular results. This review covers important pre‐analytic considerations and limitations, and a description of common ...
Scott A. Turner, Rand Abou Shaar, Zhongbo Yang   +2 more
wiley   +1 more source