Results 231 to 240 of about 328,798 (314)

Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Marius Müller, Nadia Bom Pedersen, Vladimir Shalgunov, Andreas Ingemann Jensen, Umberto Maria Battisti, Matthias Manfred Herth   +5 more
wiley   +1 more source

12214 Metastatic Functional Thyroid Carcinoma As An Unusual Cause Of Hyperthyroidism

Silvana Jiménez-Salazar, Natalia Aristizábal Henao, Carolina Aguilar Londoño, Nathalia Buitrago Gómez, Santiago Saldarriaga Betancur, Diego Leonardo Beltran, Jose Torres   +6 more
openalex   +1 more source

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

Medicinal Research Reviews, EarlyView.
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca, Gianluca Baldanzi, Alberto Massarotti   +2 more
wiley   +1 more source

Renal metastasis from papillary thyroid carcinoma: A rare case report. [PDF]

Front Oncol
Huang W, Hou Z, Lin Y, Bai Q, Yuan M, Yuan P.   +5 more
europepmc   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Coexistence of Severe Valvular Pulmonary Stenosis and Papillary Thyroid Carcinoma: A Rare Association or Coincidence? [PDF]

Cureus
Alshehri MR, Hamad AM, Othman RM, Shahball OA.   +3 more
europepmc   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Minimal or absent tumor desmoplasia predicts lower recurrence risk in papillary thyroid carcinoma. [PDF]

Eur Thyroid J
Piticchio T, Piombino E, Galeano F, Volpe S, Prinzi A, Barca I, Tumminia A, Malandrino P, Tumino D, Russo M, Le Moli R, Wolde Sellasie S, Pallotti F, Trimboli P, Bartoloni G, Frasca F.   +15 more
europepmc   +1 more source

Sporadic medullary thyroid carcinoma with a rare RET transmembrane domain mutation (A641R) that responds to selpercatinib [PDF]

Naoki Fukuda, Kazuhisa Toda, Tomohiro Chiba, Ippei Fukada, Seiichi Mori, Akiko Tonooka, Erisa Toda, Jumpei Yoshida, Xiaofei Wang, Ryosuke Oki, Takehiro Nakao, Tetsuya Urasaki, Kenji Nakano, Makiko Ono, Junichi Tomomatsu, Kengo Takeuchi, Shunji Takahashi, Yuji Miura   +17 more
openalex   +1 more source

Pharmacokinetic modeling strategies for dynamic hyperpolarized urea imaging

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose To evaluate pharmacokinetic modeling methods for quantification of tissue perfusion/permeability with hyperpolarized 13C urea. Methods Three models for quantitative analysis of dynamic HP urea imaging data were proposed and evaluated in numerical simulations and a thyroid cancer mouse model.
Keith A. Michel, Collin J. Harlan, Christopher M. Walker, Matthew E. Merritt, Yunyun Chen, Stephen Y. Lai, James A. Bankson   +6 more
wiley   +1 more source