Results 61 to 70 of about 335,864 (307)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Maternal urinary bisphenol a during pregnancy and maternal and neonatal thyroid function in the CHAMACOS study. [PDF]

, 2013
BackgroundBisphenol A (BPA) is widely used in the manufacture of polycarbonate plastic bottles, food and beverage can linings, thermal receipts, and dental sealants. Animal and human studies suggest that BPA may disrupt thyroid function. Although thyroid
Bradman, Asa, Calafat, Antonia M, Chevrier, Jonathan, Eskenazi, Brenda, Gunier, Robert B, Harley, Kim G, Holland, Nina T   +6 more
core   +1 more source

Thyroid hormone, thyroid hormone receptors, and cancer: a clinical perspective [PDF]

Endocrine-Related Cancer, 2013
Thyroid hormones (THs) may play a role in diseases other than hyper- and hypothyroidism. Several lines of evidence suggest tumor-promoting effects of TH and TH receptors. They are possibly mediated by phosphatidylinositol-3-kinase and MAPK and involve among others stimulation of angiogenesis via αvβ3.
Möller, Lars, Führer, Dagmar
openaire   +3 more sources

Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro, María Victoria Zelaya, Hasier Eraña, Javier Sánchez Ruiz de Gordoa, Fermín García‐Amigot, Anika Simonovska‐Serra, María Cristina Caballero, Isidre Ferrer, Ellen Gelpi, Ivonne Jericó, Joaquín Castilla   +10 more
wiley   +1 more source

Sick euthyroid syndrome: A myth or reality

Journal of Pediatric Critical Care, 2017
Altered thyroid function in non-thyroidal illness(NTI) is a well-recognized finding. The term euthyroid sick syndrome (SES) identifies abnormalities in thyroid function observed in patients with systemic nonthyroidal illnesses (NTIs).
Vinayak Patki, Aniket Kumbhojkar, Praveen Khilnani   +2 more
doaj   +1 more source

Association between Sensitivity to Thyroid Hormone Indices and Bone Mineral Density in US Males

International Journal of Endocrinology, 2022
Objectives. Thyroid hormone is acknowledged as a pivotal factor in skeletal development and adult bone maintenance. However, available data about the relationship between sensitivity to thyroid hormone and bone mineral density (BMD) remain limited and ...
Shuai Chen, Wucui Huang, Guowei Zhou, Xiaohe Sun, Jie Jin, Zhiwei Li   +5 more
doaj   +1 more source

Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report [PDF]

, 2017
There is a frequently encountered subset of hypothyroid patients who are refractory to standard thyroid hormone replacement treatment and require unexpectedly high doses of levothyroxine.
Benvenga, S, Centanni, Marco, Sachmechi, I.   +2 more
core   +1 more source

Thyroid Hormones and Mitochondria

Bioscience Reports, 2002
Because of their central role in the regulation of energy-transduction, mitochondria, the major site of oxidative processes within the cell, are considered a likely subcellular target for the action that thyroid hormones exert on energy metabolism. However, the mechanism underlying the regulation of basal metabolic rate (BMR) by thyroid hormones still ...
GOGLIA F., SILVESTRI E., LANNI, Antonia
openaire   +3 more sources

A 73‐Year‐Old Man With Several Years of Difficulty Climbing Stairs and Frequent Tripping

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 73‐year‐old man presented with progressive weakness and atrophy predominantly affecting the distal finger flexors and quadriceps muscles. Electrophysiological studies demonstrated mixed myogenic and neurogenic features. Muscle MRI showed inflammatory changes, and muscle biopsy revealed granulomatous myositis with histologic features ...
Mehmet Can Sari, Arens Taga, Sonya Ulrike Steele, Ahmet Hoke   +3 more
wiley   +1 more source