Results 121 to 130 of about 175,066 (304)

Thyroid hormone regulates distinct paths to maturation in pigment cell lineages [PDF]

, 2019
Thyroid hormone (TH) regulates diverse developmental events and can drive disparate cellular outcomes. In zebrafish, TH has opposite effects on neural crest derived pigment cells of the adult stripe pattern, limiting melanophore population expansion, yet
Aman, Andrew J, Corbo, Joseph C, Lewis, Victor M, McFaline-Figueroa, Jose L, Mishra, Abhishek K, Packer, Jonathan S, Parichy, David M, Qiu, Xiaojie, Saunders, Lauren M, Toomey, Matthew B, Trapnell, Cole   +10 more
core   +1 more source

Mitigating subtherapeutic cabozantinib exposure after prior mitotane therapy in adrenocortical carcinoma: Pharmacological boosting with cobicistat

British Journal of Clinical Pharmacology, EarlyView.
Mitotane is an adrenolytic drug with cytotoxic effects, registered for the treatment of advanced adrenocortical carcinoma (ACC), a rare but aggressive tumour type with a poor prognosis despite treatment. Recently, the oral multi‐kinase inhibitor cabozantinib has shown promising results as a potential second‐line treatment option.
Annemieke M. Peters van Ton, Nielka P. van Erp, Annenienke C. van de Ven, Janneke E. W. Walraven, Loek A. W. de Jong   +4 more
wiley   +1 more source

Resistance to Thyroid Hormone with Missense Mutation (V349M) in the Thyroid Hormone Receptor Beta Gene [PDF]

, 2008
Ji Yon Kim, Eun Suk Choi, Jong Chan Lee, Kyung Uk Lee, Yeo Joo Kim, Sang Jin Kim, Yong Wha Lee   +6 more
openalex   +1 more source

Binding and Activity of Tetrabromobisphenol A Mono-Ether Structural Analogs to Thyroid Hormone Transport Proteins and Receptors [PDF]

, 2020
Xiaomin Ren, Linlin Yao, Xue Qiao, Jianbo Shi, Qinghua Zhang, Pu Wang, Jianjie Fu, Aiqian Zhang, Guangbo Qu, Guibin Jiang   +9 more
openalex   +1 more source

Levothyroxine effects on depressive symptoms and limbic glucose metabolism in bipolar disorder: a randomized, placebo-controlled positron emission tomography study. [PDF]

, 2016
Adding supraphysiologic doses of levothyroxine (L-T4) to standard treatment for bipolar depression shows promise, but the mechanisms underlying clinical improvement are unknown.
Adli, M, Bauer, M, Berman, S, Hellemann, GS, London, ED, Pilhatsch, M, Plotkin, M, Schlagenhauf, F, Stamm, T, Whybrow, PC   +9 more
core  

Effect of progestin on thyroid function in female Wistar rats

Frontiers in Endocrinology
IntroductionTo characterize the influence of female-specific hormones on women’s thyroid function, the study investigated the influence of extra progestin from oral contraceptives on inducing thyroid dysfunction.MethodsSixty female Wistar rats were ...
Honglei Xie, Tingting Qian, Tingting Qian, Lanchun Liu, Rong Sun, Wenjing Che, Meng Zhao, Xin Hou, Haowen Pan, Yue Su, Jia Li, Xiaoqiu Dong, Xiaoqiu Dong, Peng Liu, Peng Liu   +14 more
doaj   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

An Investigation of Hyperostosis Frontalis Interna in a Modern Anatomical Body Donor Population

Clinical Anatomy, EarlyView.
ABSTRACT This research sought to examine the prevalence and severity of hyperostosis frontalis interna (HFI) in the Chicagoland anatomical body donor population. The study further aimed to elucidate potential demographic risk factors for HFI, including sex, age at death, and structural vulnerability index (SVI), as well as any common comorbidities, as ...
Amy C. Beresheim, Amanda Hall
wiley   +1 more source

A neomutation of the thyroid-stimulating hormone receptor in a severe neonatal hyperthyroidism. [PDF]

, 1996
Nicolás de Roux, Michel Polak, Jacques Couët, Juliane Léger, P Czernichow, Edwin Milgröm, Micheline Misrahi   +6 more
openalex   +1 more source

Unfolded protein response kinase PERK supports survival and metastasis of circulating tumor cell clusters via SAM synthesis and H3K4me3‐dependent PDGFB signaling

Cancer Communications, EarlyView.
Abstract Background Metastasis is the leading cause of cancer‐related mortality, with circulating tumor cell (CTC) clusters serving as highly efficient precursors of distant metastasis. Survival of CTC clusters in the bloodstream is the primary contributor to tumor metastasis.
Rui Tang, Yan Sun, Ao Deng, Jiahe Liu, Peijin Dai, Jing Chen, Chaoqun Deng, Hui Liu, Yuhang Hai, Yanran Tong, Yan‐e Du, Manran Liu, Haojun Luo   +12 more
wiley   +1 more source