Results 111 to 120 of about 26,033 (150)

Brain fatigue in Graves' disease: symptoms and presentation of a possible mechanism at the cellular level. [PDF]

Eur Thyroid J
Tammelin K, Holmberg M, Lindo A, Johansson B, Rönnbäck L, Nyström HF.   +5 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Three new mutations of thyroid hormone receptor-beta associated with resistance to thyroid hormone.

The Journal of Clinical Endocrinology & Metabolism, 1994
Three novel point mutations at nucleotides 1249, 1282, and 1614 (exons 9 and 10) of the human thyroid hormone receptor-beta gene were observed in six individuals affected by the syndrome of resistance to thyroid hormone. All three mutations occurred in a heterozygous pattern and caused the following changes in the mature form of the receptor protein ...
Bartolone, L, Regalbuto, C, Benvenga, S, Filetti, S, Trimarchi, F, Pontecorvi, Alfredo   +5 more
openaire   +4 more sources

A case of resistance to thyroid hormone without mutation in the thyroid hormone receptor beta

Irish Journal of Medical Science, 2005
Resistance to Thyroid Hormone (RTH) is a condition caused by tissue hyposensitivity to the effects of circulating thyroid hormone, and may be misdiagnosed as hyperthyroidism.We report the first case of RTH in an Irish patient highlighting the clinical features and the pathophysiological mechanism underlying the characteristic laboratory abnormalities ...
J H, McDermott, A, Agha, M, McMahon, D, Gasparro, L, Moeller, A M, Dumitrescu, S, Refetoff, S, Sreenan   +7 more
openaire   +2 more sources

Mild resistance to thyroid hormone with a truncated thyroid hormone receptor ß

Experimental and Clinical Endocrinology & Diabetes, 2009
Recent studies have revealed mutations in the thyroid hormone receptor beta (TR beta) gene as a cause of the most cases of the thyroid hormone resistance syndrome. We have identified a novel nonsense mutation in codon 449 in the 3' end of exon 10 in the TR beta gene in a 16-year-old male patient with generalized resistance to thyroid hormone who also ...
M, Taniyama, S, Kusano, Y, Miyoshi, H, Nakamura, M, Kaihara, T, Tobe, M, Tomita, T, Katagiri, Y, Ban   +8 more
openaire   +2 more sources

Human Genetics of Thyroid Hormone Receptor Beta: Resistance to Thyroid Hormone Beta (RTHβ)

2018
Resistance to thyroid hormone beta (RTHβ) is a syndrome characterized by reduced responsiveness of peripheral tissues to thyroid hormone (TH). Affected individuals have consistently high TH levels and non-suppressed thyrotropin in the absence of acute illness, drugs, or alterations in TH binding proteins.
Theodora, Pappa, Samuel, Refetoff
openaire   +2 more sources

Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta

Bioorganic & Medicinal Chemistry Letters, 2004
A set of thyromimetics having improved selectivity for TR-beta1 were prepared by replacing the 3'-isopropyl group of 2 and 3 with substituents having increased steric bulk. From this limited SAR study, the most potent and selective compounds identified were derived from 2 and contained a 3'-phenyl moiety bearing small hydrophobic groups meta to the ...
Jon J, Hangeland, Arthur M, Doweyko, Tamara, Dejneka, Todd J, Friends, Pratik, Devasthale, Karin, Mellström, Johnny, Sandberg, Marlena, Grynfarb, John S, Sack, Howard, Einspahr, Mathias, Färnegårdh, Bolette, Husman, Jan, Ljunggren, Konrad, Koehler, Cheryl, Sheppard, Johan, Malm, Denis E, Ryono   +16 more
openaire   +2 more sources

A Novel Familial Variation of the Thyroid Hormone Receptor Beta Gene (I276N) Associated with Resistance to Thyroid Hormone

Thyroid, 2012
Background: Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome characterized by reduced organ responsiveness to thyroid hormone, with elevated thyroid hormone levels and unsuppressed TSH concentrations, and a widely variable clinical phenotype.
Monzani A, Moia S, Prodam F, Walker GE, Bellone S, Petri A, Bona G.   +6 more
openaire   +3 more sources

Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the thyroid hormone beta 1-receptor protein.

Endocrinology, 1994
Desethylamiodarone (DEA), the major metabolite of the potent antiarrythmic drug amiodarone, is a non-competitive inhibitor of the binding of thyroid hormone (T3) to the beta 1-thyroid hormone receptor (T3R). In the present study, we investigated whether DEA acts in a similar way with respect to the alpha 1-T3R.
Bakker, O., van Beeren, H. C., Wiersinga, W. M.   +2 more
openaire   +3 more sources

QSAR study of selective ligands for the thyroid hormone receptor β

Bioorganic & Medicinal Chemistry, 2007
In this paper, an accurate and reliable QSAR model of 87 selective ligands for the thyroid hormone receptor beta 1 (TRbeta1) was developed, based on theoretical molecular descriptors to predict the binding affinity of compounds with receptor. The structural characteristics of compounds were described wholly by a large amount of molecular structural ...
LIU H, GRAMATICA, PAOLA
openaire   +2 more sources