Thyroid Hormones and Cancer: A Comprehensive Review of Preclinical and Clinical Studies
Frontiers in Endocrinology, 2019 Thyroid hormones take major part in normal growth, development and metabolism. Over a century of research has supported a relationship between thyroid hormones and the pathophysiology of various cancer types.
Eilon Krashin +7 more
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Intranasal delivery of Thyroid hormones in MCT8 deficiency.
PLoS ONE, 2020 Loss of function mutations in the gene encoding the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) lead to severe neurodevelopmental defects in humans associated with a specific thyroid hormone phenotype manifesting high serum 3,5,3 ...
Carmen Grijota-Martínez +5 more
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Triiodothyronine and free thyroxine levels are differentially associated with metabolic profile and adiposity-related cardiovascular risk markers in euthyroid middle-aged subjects [PDF]
, 2014 Background: We previously showed that in healthy young men a less favorable body composition is associated with higher FT3 levels within the euthyroid range.
De Buyzere, Marc +6 more
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Role of maternal thyroid hormones in the developing neocortex and during human evolution
Frontiers in Neuroanatomy, 2013 The importance of thyroid hormones during brain development has been appreciated for many decades. In humans, low levels of circulating maternal thyroid hormones, e.g.
Denise eStenzel, Wieland B eHuttner
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Thyroid hormone sensitivity and diabetes onset: a longitudinal cross-lagged cohort
Frontiers in Endocrinology, 2023 PurposeThyroid hormones sensitivity is a newly proposed clinical entity closely related with metabolic health. Prior studies have reported the cross-sectional relationship between thyroid hormones sensitivity and diabetes; however, the longitudinal ...
Cancan Cui +8 more
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Folia Endocrinologica Japonica, 1993 Most thyroxine (T4) secreted from the thyroid is deiodinated in peripheral tissues. At least three isozymes are known in iodothyronine deiodinase which catalyzes the conversion of T4 to triiodothyronine (T3) or reverse T3. Type I 5'-deiodinase (5'D-I) exists in most tissues including the liver, kidney and thyroid.
M, Inada, M, Nishikawa
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Journal of Nutritional Science, 2021 Maternal thyroid hormones facilitate optimal foetal neurodevelopment; however, the exact role of the thyroid hormones on specific cognitive outcomes is unknown.
Anna M. Monaghan +10 more
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Thyroid hormone levels within reference range are associated with heart rate, cardiac structure, and function in middle-aged men and women [PDF]
, 2013 Background: Triiodothyronine (T3) has many effects on the heart, and marked changes in cardiac function and structure occur in patients with (subclinical) thyroid disease. We investigated whether between-subject variation in thyroid hormone levels within
De Buyzere, Marc +6 more
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Main Factors Involved in Thyroid Hormone Action
Molecules, 2021 The thyroid hormone receptors are the mediators of a multitude of actions by the thyroid hormones in cells. Most thyroid hormone activities require interaction with nuclear receptors to bind DNA and regulate the expression of target genes. In addition to
Lorena Tedeschi +3 more
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Endocrine factors in the hypothalamic regulation of food intake in females: a review of the physiological roles and interactions of ghrelin, leptin, thyroid hormones, oestrogen and insulin [PDF]
, 2011 Controlling energy homeostasis involves modulating the desire to eat and regulating energy expenditure. The controlling machinery includes a complex interplay of hormones secreted at various peripheral endocrine endpoints, such as the gastrointestinal ...
Bartha, Tibor +7 more
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