Results 31 to 40 of about 90,983 (266)

Thyroid Disorders and Chronic Kidney Disease

International Journal of Nephrology, 2014
Thyroid hormones play a very important role regulating metabolism, development, protein synthesis, and influencing other hormone functions. The two main hormones produced by the thyroid are triiodothyronine (T3) and thyroxine (T4).
Mohamed Mohamedali, Srikanth Reddy Maddika, Anix Vyas, Viswanathan Iyer, Pramil Cheriyath   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Thyroid Functioning in Diabetes Mellitus Complicated with Chronic Renal Disease

Mìžnarodnij Endokrinologìčnij Žurnal, 2013
Thyroid hormones affect renal physiological development, kidney structure, renal hemodynamics, glomerular filtration rate, the function of a number of nephron transport systems, and water-electrolyte metabolism.
Ye.G. Sazonova, T.V. Mokhort
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Thyroid dysfunction in the ageing patient

Mìžnarodnij Endokrinologìčnij Žurnal
Thyroid dysfunction is a common endocrine disorder in the general population, with a reported prevalence of 10–15 %. This rate is higher in older adults, with an estimated prevalence of 25 % in some populations.
O.V. Bilookyi, V.L. Vasiuk, O.A. Shupik
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Measurement of salivary thyroid hormones using the LC-MS/MS technique in a clinical setting

Therapeutic Advances in Endocrinology and Metabolism
Background: Saliva could be an attractive alternative to blood for assessing thyroid hormonal function. Objectives: Our goal was to determine if the levels of thyroid hormones in saliva can accurately reflect a person’s thyroid status and if they ...
Nadia Sawicka-Gutaj, Piotr Glinicki, Kacper Nijakowski, Barbara Bromińska, Magdalena Ostrowska, Alicja Szatko, Zuzanna Sobol, Konrad Kowalski, Paweł Wilk, Wojciech Zgliczyński, Marek Ruchała   +10 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The Relation-Ship Between Anti-Thyroidal Peroxidise Antibodies (TPO-Abs) and Thyroid Hormones (T3, T4 and Thyroid Stimulating Hormone TSH) among Patients of Autoimmune Thyroid Disease (AITD).

Kufa Journal for Nursing Sciences, 2014
Objectives: This Study was designed to investigate the role of the auto antibodies against thyroid peroxidise (TPO-Abs) and thyroid Hormones (T3, T4, TSH) in pathogenesis of Autoimmune Thyroid Disease (AITD).
Hashim Rahim Taresh, Rawaa Behlul Majhul Al-Fatlawi, Salman Aziz Al-Juburi   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source