Results 11 to 20 of about 2,123,224 (289)

Iodothyronine deiodinases and reduced sensitivity to thyroid hormones [PDF]

Frontiers in Bioscience-Landmark, 2020
Iodothyronine deiodinases are selenoproteins that regulate thyroid hormone metabolism. Of the three types of deiodinases, type 2 is the major regulator of intracellular triiodothyronine concentration in both the hypothalamus and pituitary, and therefore ...
Rosa Maria Paragliola, Andrea Corsello, Paola Concolino, Francesca Ianni, Giampaolo Papi, Alfredo Pontecorvi, Salvatore Maria Corsello   +6 more
doaj   +6 more sources

Tissue sensitivity to thyroid hormones may change over time [PDF]

European Thyroid Journal, 2022
Introduction Patients with congenital hypothyroidism (CH) may transiently show a certain degree of pituitary resistance to levothyroxine (LT4) which, however, normalizes subsequently. However, in some individuals, thyroid-stimulating hormone (TSH) fails to normalize despite adequate LT4 treatment.
Radetti, Giorgio, Rigon, Franco, Salvatoni, Alessandro, Campi, Irene, De Filippis, Tiziana, Cirello, Valentina, Longhi, Silvia, Guizzardi, Fabiana, Bonomi, Marco, Persani, Luca   +9 more
core   +5 more sources

Impaired Sensitivity to Thyroid Hormones is Associated with Mild Cognitive Impairment in Euthyroid Patients with Type 2 Diabetes

Clinical Interventions in Aging, 2023
Zi-Wei Yu,1,* Sheng-Dan Pu,2,* Xiao-Tong Sun,2 Xi-Chang Wang,1 Xin-Yuan Gao,2 Zhong-Yan Shan1 1Department of Endocrinology and Metabolism and the Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases ...
Yu ZW, Pu SD, Sun XT, Wang XC, Gao XY, Shan ZY   +5 more
doaj   +1 more source

Changes in Central Sensitivity to Thyroid Hormones vs. Urine Iodine during Pregnancy

Medical Sciences
Introduction/Aim: Central sensitivity to thyroid hormones refers to the responsiveness of the hypothalamic–pituitary–thyroid (HPT) axis to changes in circulating free thyroxine (fT4).
Ioannis Ilias, Charalampos Milionis, Maria Alexiou, Ekaterini Michou, Chrysi Karavasili, Evangelia Venaki, Kostas Markou, Irini Mamali, Eftychia Koukkou   +8 more
doaj   +2 more sources

Sensitivity to thyroid hormone indices are associated with papillary thyroid carcinoma in Chinese patients with thyroid nodules

BMC Endocrine Disorders, 2023
Background The association between thyroid hormone sensitivity and thyroid cancer is unknown, and we aimed to investigate the association between sensitivity to thyroid hormone indices and papillary thyroid carcinoma (PTC) in Chinese patients with ...
Jie Sun, Jie Liu, Ting-ting Wu, Zhi-yuan Gu, Xiao-wen Zhang   +4 more
doaj   +3 more sources

Association between sensitivity to thyroid hormones and trabecular bone score in euthyroid individuals: a population-based cross-sectional study

BMC Musculoskeletal Disorders
Background Thyroid hormone is a known pivotal factor that affects bone metabolism; however, whether bone microarchitecture is associated with thyroid hormone sensitivity is poorly understood.
Zihan Chen, Yuxiong Chen, Yuanmeng Li, Zhiwei Leng, Naishi Li, Weibo Xia   +5 more
doaj   +2 more sources

Reduced sensitivity to thyroid hormones is associated with differentiated thyroid cancer in the euthyroid thyroidectomy population

Frontiers in Endocrinology
BackgroundThe inconclusive associations between thyroid-related hormones and differentiated thyroid cancer (DTC) suggest complex pathophysiologic processes, for which thyroid hormone sensitivity may provide new insights.MethodsWe retrospectively analyzed
Huaijin Xu, Huaijin Xu, Hongzhou Liu, Xiaodong Hu, Xiaomeng Jia, Zhe Xue, Anning Wang, Shaoyang Kang, Shaoyang Kang, Zhaohui Lyu, Zhaohui Lyu   +10 more
doaj   +3 more sources

Longitudinal evidence of the impact of normal thyroid stimulating hormone variations on cognitive functioning in very old age [PDF]

, 2008
The purpose of this study was to examine longitudinal associations among thyroid stimulating hormone (TSH) levels and cognitive performance. Data collected at the first three assessment times, approximately 3 years apart, are reported for the survivors ...
Wahlin, TBR, Wahlin, A, Bunce, D
core   +6 more sources

Reduced Sensitivity to Thyroid Hormone Is Associated with Diabetes and Hypertension [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2021
Abstract Context Recently, reduced sensitivity to thyroid hormone as a more common finding in the general population and its possible association with metabolic parameters has been the focus of attention.
Ladan Mehran, Negar Delbari, Atieh Amouzegar, Mitra Hasheminia, Maryam Tohidi, Fereidoun Azizi   +5 more
openaire   +6 more sources

The syndromes of reduced sensitivity to thyroid hormone [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2013
Six known steps are required for the circulating thyroid hormone (TH) to exert its action on target tissues. For three of these steps, human mutations and distinct phenotypes have been identified.The clinical, laboratory, genetic and molecular characteristics of these three defects of TH action are the subject of this review.
Alexandra M, Dumitrescu, Samuel, Refetoff   +1 more
openaire   +2 more sources