Results 81 to 90 of about 190,183 (351)

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes [PDF]

, 2016
Background The cardiovascular effect of liraglutide, a glucagon-like peptide 1 analogue, when added to standard care in patients with type 2 diabetes, remains unknown. Methods In this double-blind trial, we randomly assigned patients with type 2 diabetes
Bergenstal, RM, Brown-Frandsen, K, Buse, JB, Daniels, GH, Kristensen, P, LEADER Steering Committee on behalf of the LEADER Trial Investigators, Mann, JF, Marso, SP, Nauck, MA, Nissen, SE, Pocock, S, Poulter, NR, Ravn, LS, Steinberg, WM, Stockner, M, Zinman, B   +15 more
core   +1 more source

Advances in Electrochemical Urea Biosensors: Trends and Future Prospects

Advanced Sensor Research, EarlyView.
This review explores advances in enzymatic and non‐enzymatic biosensors, emphasizing electrochemical detection, material innovations, and IoT integration for real‐time tracking. Key challenges and future opportunities in enhancing sensitivity, selectivity, and portability are highlighted, showcasing biosensors as promising tools for next‐generation ...
Samar Shurbaji, Arshad Khan, Mohammad K. Hassan, Amine Bermak, Wen‐Di Li, Kabir H Biswas, Bo Wang   +6 more
wiley   +1 more source

Unmodifiable variables related to thyroid cancer incidence [PDF]

, 2018
The incidence of thyroid cancer is significantly different between male and female patients. Thyroid cancer is also the only form of cancer where age can be considered a staging variable.
Alecu, Lucian, Hainarosie, Razvan, Jecan, Radu C., Nitipir, Cornelia, Orlov, Cristina, Pituru, Silviu, Slavu, Iulian, Stanculeanu, Dana L., Stoian, Anca P., Tulin, Adrian, Tulin, Raluca   +10 more
core   +2 more sources

Replacing BPA: Structural Substitutes BPAF Binding to the Progesterone Receptor Elevates Breast Cancer Risk

Advanced Science, EarlyView.
This study demonstrates that bisphenol analogues, particularly BPAF, bind to progesterone receptor, promoting breast cancer cell proliferation, migration, and mammary tumor growth, indicating that bisphenol A substitutes may pose equal or greater health risks.
Xiaotong Ji, Peilin Li, Haoyang Wu, Linzhuo Shen, Xiaoyun Wu, Peiyun Jiang, Yating Li, Xiaozheng Zhang, Huifeng Yue   +8 more
wiley   +1 more source

Cowden syndrome - Diagnostic skin signs [PDF]

, 2001
Cowden syndrome is a rare autosomal dominant familial cancer syndrome with a high risk of breast cancer. The most important clinical features include carcinomas of the breast and thyroid, and hamartomatous polyps of the gastrointestinal tract.
Burgdorf, Walter H. C., Hildenbrand, C., Lautenschlager, Stephan   +2 more
core   +1 more source

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source

The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]

, 2020
Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J, Kato, Shumei, Kurzrock, Razelle, Lippman, Scott M   +3 more
core  

Thyroid Cancer in Regions Most Contaminated after the Chernobyl Disaster [PDF]

Journal of Biomedical Physics and Engineering
Exposure to ionizing radiation, especially during childhood, is a well-established risk factor for thyroid cancer. Following the 1986 Chernobyl nuclear power plant accident the total number of cases of thyroid cancer registered between 1991 and 2015 in ...
Marek K. Janiak, Grzegorz Kamiński
doaj   +1 more source

Disruption of NF‐κB‐Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis

Advanced Science, EarlyView.
This study reveals a feedback mechanism regulating copper homeostasis, in which copper directly interacts with TAK1 to activate NF‐κB signaling, while NF‐κB transcriptionally suppresses copper transporter (CTR1) expression. These findings highlight a promising therapeutic strategy for breast cancer by combining NF‐κB inhibitors with copper chelators or
Xiaomei Zhang, Yaqing Su, Weixiong Yang, Zimin Song, Zicheng Sun, Xueji Wu, Jianwen Chen, Bing Gao, Zekang Wang, Lei Wang, Qiwei Jiang, Lang Bu, Jingting Li, Ying Lin, Wei Xie, Jie Li, Jianping Guo   +16 more
wiley   +1 more source

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source