Results 201 to 210 of about 89,227 (287)

mTORC1‐USP30‐LEF1 Cascade Regulates Cancer Stemness and Malignant Progression Through Mitonuclear Crosstalk

open access: yesMedComm, Volume 6, Issue 12, December 2025.
Nutrient deprivation triggers USP30 nuclear translocation via an N‐terminal nuclear localization signal (NLS), mediated through suppression of mTORC1‐dependent phosphorylation at serine 104, a modification constraining nuclear entry. Nuclear USP30 deubiquitinates TCF/LEF1 at K379 and K382 residues, disrupting recruitment of CBP/P300 co‐activators to ...
Xiaolin Li   +15 more
wiley   +1 more source

Mutation profiling in differential diagnosis between TdT‐positive high‐grade/large B‐cell lymphoma and B‐lymphoblastic leukaemia/lymphoma

open access: yesThe Journal of Pathology, Volume 267, Issue 4, Page 410-423, December 2025.
Abstract Terminal deoxynucleotidyl transferase (TdT) is occasionally expressed in large B‐cell lymphoma (LBCL), and this causes difficulty in differential diagnosis from B‐lymphoblastic leukaemia/lymphoma (B‐ALL/LBL). We reviewed 31 cases of TdT‐positive LBCL and B‐ALL/LBL, and their final diagnosis included 19 diffuse large/high‐grade BCLs with MYC ...
Maria‐Myrsini Tzioni   +27 more
wiley   +1 more source

Diagnostic accuracy of thyroid nodules with indeterminate cytology when combined with ultrasonographic risk. [PDF]

open access: yesSaudi Med J
Samargandy SA   +7 more
europepmc   +1 more source

Enhancing Sonography Through a Clinical Fellowship Model

open access: yesSonography, Volume 12, Issue 4, Page 422-424, December 2025.
ABSTRACT This commentary examines the implementation and outcomes of a Sonographer Clinical Fellowship Program (SCFP) within a large tertiary hospital. The SCFP was developed in response to increasing demands for subspecialist expertise, rapid technological advancements, and persistent workforce shortages in sonography.
P. R. Coombs   +6 more
wiley   +1 more source

Malignancy prediction for calcified thyroid nodules using deep learning based on ultrasound dynamic videos. [PDF]

open access: yesCancer Imaging
Qian T   +10 more
europepmc   +1 more source

DIAGNOSTIC ACCURACY OF ULTRASONOGRAPHY IN DIFFERENTIATING BENIGN AND MALIGNANT THYROID NODULES

open access: diamond, 2023
SKF KHALIL   +5 more
openalex   +2 more sources

Targets and strategies to design soybean seed composition traits

open access: yesThe Plant Genome, Volume 18, Issue 4, December 2025.
Abstract Breeders and geneticists have put great effort into enhancing soybean seed composition and developing elite varieties with desired traits. However, diverse end‐uses and changing consumer preferences present new challenges and opportunities to develop desired compositional profiles for the market.
Ritesh Kumar   +9 more
wiley   +1 more source

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