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Late Reactivation of Thyroid Orbitopathy
Clinical and Experimental Ophthalmology, 2004 Abstract Background: Thyroid orbitopathy is characterized by spontaneous remissions and exacerbations. Although data on the natural history are scarce, the active phase is usually self‐limited, encompassing an average period of 18−36 months. Late reactivation, defined as active orbitopathy occurring after more than 5 years of quiescent disease, appears
Dinesh Selva, Dinesh Selva Franzco
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Pathophysiology of thyroid-associated orbitopathy
Best Practice & Research Clinical Endocrinology & Metabolism, 2023Thyroid-associated orbitopathy, the most common extrathyroidal manifestation of Graves' disease, is characterized by orbital inflammatory infiltration and activation of orbital fibroblasts, which mediates de novo adipogenesis, excessive production of hyaluronan, myofibroblast differentiation and ultimately tissue fibrosis. Interactions among T cells, B
Alan Chun Hong, Lee, George J, Kahaly
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Thyroid associated orbitopathy
Odisha Journal of Ophthalmology, 2022Thyroid-associated orbitopathy (TAO) is the most frequent extrathyroidal manifestation of Graves’ disease. It is an autoimmune process affecting the retrobulbar tissue. It is the most common cause of bilateral and unilateral exophthalmos among adults.
Sharmistha Behera +3 more
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Ultrasound in Early Thyroid Orbitopathy
Archives of Ophthalmology, 1980Fourteen patients with unilateral exophthalmos were found on A-scan ultrasound examination to have enlarged extraocular muscles. Thyroid dysfunction later was documented in 12 patients (86%) by laboratory tests and subsequent clinical examination. The suspicion of endocrine orbitopathy was based on the presence of enlarged extraocular muscles in both ...
H J, Shammas, D S, Minckler, C, Ogden
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Surgical management of thyroid orbitopathy
Journal of Plastic, Reconstructive & Aesthetic Surgery, 2010To examine the outcomes of orbital surgical decompression in patients affected by thyroid orbitopathy with mild-to-severe proptosis. The surgical procedures included fat removal alone or combined with orbital bone walls fracture.An analysis of a retrospective case series of 56 patients (115 orbits) who underwent orbital decompression for Graves ...
CHIARELLI AGM +4 more
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Total thyroid ablation in Graves’ orbitopathy
Journal of Endocrinological Investigation, 2015Graves' orbitopathy (GO) is an autoimmune condition almost always associated with autoimmune thyroid disease, especially Graves' disease (GD). According to the most widely accepted model, the autoantigens responsible for GO would include molecules expressed by thyroid epithelial cells that are present also in orbital tissues.
Menconi, Francesca +4 more
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Thyroid Volume and Severity of Graves' Orbitopathy
Thyroid, 2013Graves' orbitopathy (GO) is thought to be related to one or more autoantigens present in the thyroid and in orbital tissues. Although this may not imply a quantitative relation between thyroid antigens and degree of GO, which in turn is a risk factor for a more pronounced GO, we postulated that the severity of GO may parallel the amount of thyroid ...
Profilo MA +12 more
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Orbital decompression for thyroid orbitopathy
Australian and New Zealand Journal of Ophthalmology, 1997AbstractBackground:Severe thyroid orbitopathy may result in optic neuropathy, corneal exposure and disfiguring proptosis, Orbital decompression has most commonly been performed for optic neuropathy, but with improved techniques, more patients are undergoing decompression for other indications. Purpose: This report evaluates the results and morbidity of
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