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Thyroid associated orbitopathy
Indian Journal of Ophthalmology, 2012 Thyroid associated orbitopathy, also known as Graves' orbitopathy, is typically a self-limiting autoimmune process associated with dysthyroid states. The clinical presentation may vary from very mild disease to severe irreversible sight-threatening complications. Despite ongoing basic science and clinical research, the pathogenesis and highly effective
Rajat Maheshwari, Ezekiel Weis
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Asymmetric Graves’ Orbitopathy [PDF]
Frontiers in Endocrinology, 2020 Graves’ Orbitopathy (GO) is an autoimmune orbital disorder usually presenting as a sequala of autoimmune thyroid disease. The presence of GO is associated with increased psychological burden and, in severe cases may cause blindness. While most patients with GO present with bilateral disease, asymmetric or unilateral GO may affect a significant ...
Grigorios Panagiotou, Petros Perros
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Microbiome and Graves’ Orbitopathy [PDF]
European Thyroid Journal, 2020 <b><i>Background:</i></b> Studies from animal models of autoimmunity have highlighted the potential importance of microorganisms and their metabolic products in shaping the immune system. <b><i>Summary:</i></b> This review provides an introduction to the current state-of-the-art in microbiome research ...
Giulia, Masetti, Marian, Ludgate
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Orbital Signaling in Graves’ Orbitopathy [PDF]
Frontiers in Endocrinology, 2021 Graves’ orbitopathy (GO) is a complex and poorly understood disease in which extensive remodeling of orbital tissue is dominated by adipogenesis and hyaluronan production. The resulting proptosis is disfiguring and underpins the majority of GO signs and symptoms.
Mohd Shazli Draman +4 more
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IgG4 as a Biomarker in Graves’ Orbitopathy [PDF]
Mediators of Inflammation, 2021 Immunoglobulin G4‐related disease (IgG4‐RD) is a chronic inflammatory disorder associated with fibrosis and abundant tissue lymphoplasmacytic infiltrations. It typically affects the pancreas, the salivary glands, and the retroperitoneal space. However, it might also involve multiple other organs, including the orbit and the thyroid. Recent studies have
Michał Olejarz +5 more
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Thyroid-Associated Orbitopathy [PDF]
Seminars in Plastic Surgery, 2007 Thyroid-associated orbitopathy (TAO) is usually diagnosed clinically. Early presentation of TAO such as ocular irritation, lid puffiness, and mild retraction may be overlooked and misdiagnosed. Careful clinical evaluation, laboratory investigations, and orbital imaging studies are needed for diagnosing early TAO.
Adel H, Alsuhaibani, Jeffrey A, Nerad
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Ophthalmology, 2007 Preface: Wiersinga, W.M. Kahaly, G.J. Diagnosis and Pathogenesis Clinical Manifestations: Dickinson, A.J. Orbit-Thyroid Relationship: Lazarus, J.H. Marino, M. Epidemiology: Daumerie, C. Kalmann, R. Pathogenesis: Orgiazzi, J. Orbital Imaging: Pitz, S. Diagnosis and Differential Diagnosis of Graves' Orbitopathy: Mourits, M.P.
Aparna, Bhatnagar +4 more
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Thyroid associated orbitopathy [PDF]
BMJ Case Reports, 2013 Thyroid-associated orbitopathy (TAO) is a self-limiting auto-immune condition usually associated with Grave's disease. It is characterised by ocular pain, eyelid swelling, chemosis, proptosis and keratopathy. As the mechanism for ophthamoplegia and optic neuropathy is the orbital swelling leading to mechanical restriction of ocular muscles and ...
Rajesh, Verma +2 more
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The Amsterdam Declaration on Graves' Orbitopathy [PDF]
Thyroid, 2010 For decades, clinicians who manage patients with Graves’ orbitopathy (GO) have been anticipating the emergence of new effective therapies for the management of this condition. That dream has yet to come true, but it has become apparent that conventional treatments such as steroids and surgery, when applied at the appropriate time and by centres that ...
Perros, P., Wiersinga, W.M.
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Diagnosis of Graves’ Orbitopathy
, 2023 Abstract The diagnosis of Graves’ orbitopathy is based on a typical clinical presentation, supported by a family history of Graves’ disease, in combination with typical findings on CT or MRI scans and/or elevated serum levels of TSH-receptor-binding immunoglobulins and anti-thyroid peroxidase.
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