Results 21 to 30 of about 7,373 (175)

What has changed in thyroid eye disease in the last five years (2020–2025)

European Thyroid Journal
Background: Significant progress has been made in the management of thyroid eye disease (TED), based on the elucidation of important pathogenic mechanisms. This has led to novel therapeutics validated in randomized clinical trials.
Mario Salvi
doaj   +1 more source

Exploring thyroid eye disease in Brazil: insights from a single-center study [PDF]

Archives of Endocrinology and Metabolism
Objective: Graves’ disease (GD) is the leading cause of hyperthyroidism globally, with 40% of affected individuals developing thyroid eye disease (TED). Treatment options for TED have advanced in recent years.
Danilo Villagelin, Nicolas Perini, Roberto Bernardo Santos, João Hamilton Romaldini   +3 more
doaj   +1 more source

Identification and verification of the optimal feature genes of ferroptosis in thyroid-associated orbitopathy

Frontiers in Immunology
BackgroundThyroid-associated orbitopathy (TAO) is an autoimmune inflammatory disorder of the orbital adipose tissue, primarily causing oxidative stress injury and tissue remodeling in the orbital connective tissue.
Xuemei Li, Xuemei Li, Xuemei Li, Xuemei Li, Xuemei Li, Chao Xiong, Chao Xiong, Chao Xiong, Chao Xiong, Chao Xiong, Siyi Wang, Siyi Wang, Siyi Wang, Zhangjun Ren, Zhangjun Ren, Zhangjun Ren, Qi Jin, Qi Jin, Qi Jin, Jinhai Yu, Jinhai Yu, Jinhai Yu, Jinhai Yu, Jinhai Yu, Yunxiu Chen, Yunxiu Chen, Yunxiu Chen, Puying Gan, Puying Gan, Puying Gan, Puying Gan, Qihua Xu, Qihua Xu, Qihua Xu, Qihua Xu, Qihua Xu, Yaohua Wang, Yaohua Wang, Yaohua Wang, Yaohua Wang, Yaohua Wang, Hongfei Liao, Hongfei Liao, Hongfei Liao, Hongfei Liao, Hongfei Liao   +45 more
doaj   +1 more source

Exophthalmos in a young woman with no Graves’ disease – a case report of IgG4-related orbitopathy

BMC Ophthalmology, 2018
Background Immunoglobulin G4-related disease (IgG4-rd) is characterized by lymphoplasmacytic infiltration and tissue fibrosis. Orbital manifestations of IgG4-rd may include unilateral or bilateral proptosis, cicatricial extraocular muscle myopathy ...
Annamaria Erdei, Zita Steiber, Csaba Molnar, Ervin Berenyi, Endre V. Nagy   +4 more
doaj   +1 more source

The role of pain in Graves' orbitopathy: Associations with clinical activity and quality of life

Acta Ophthalmologica, EarlyView.
Abstract Purpose Pain is included in the clinical activity score (CAS) as an indicator of inflammatory activity in Graves' orbitopathy (GO), yet its clinical relevance has not been systematically evaluated. We therefore investigated the relationship between pain, other inflammatory signs and quality of life (QoL), and assessed the effect of intravenous
Gijsbert J. Hötte, Willem A. Dik, Ronald O. B. de Keizer, Sodaba Khatab, Marco Medici, Maaike de Bie, P. Martin van Hagen, Dion Paridaens   +7 more
wiley   +1 more source

The relation between clinical response and quality of life improvement after treatment with intravenous methylprednisolone in Graves' orbitopathy

Acta Ophthalmologica, EarlyView.
Abstract Background Quality of life (QoL) is a key outcome in Graves' orbitopathy (GO), but prior studies have reported overall QoL changes without evaluating whether improvements occur specifically in patients who achieve objective clinical response.
Gijsbert J. Hötte, Willem A. Dik, Ronald O. B. de Keizer, Sodaba Khatab, M. Medici, Sigrid M. A. Swagemakers, Peter J. van der Spek, P. Martin van Hagen, Dion Paridaens   +8 more
wiley   +1 more source

Single-cell transcriptomics in thyroid eye disease

Taiwan Journal of Ophthalmology
Thyroid eye disease (TED) is a poorly understood autoimmune condition affecting the retroorbital tissue. Tissue inflammation, expansion, and fibrosis can potentially lead to debilitating sequelae such as vision loss, painful eye movement, proptosis, and ...
Sofia Ahsanuddin, Albert Y. Wu
doaj   +1 more source

Efficacy of tocilizumab in resistant forms of Thyroid Eye Disease [PDF]

Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor"
Thyroid Eye Disease (TED), formerly known as Graves' orbitopathy, is an autoimmune disorder affecting orbital tissues. The Clinical Activity Score (CAS) is used to evaluate TED activity.
Marković Bojan, Joksimović Nata, Janić Tamara, Babić Jovana, Miletić Marija, Stojković Mirjana, Nedeljković-Beleslin Biljana, Ćirić Jasmina, Žarković Miloš   +8 more
doaj   +1 more source

Inactive Graves’ orbitopathy: to treat or not to treat?

Российский офтальмологический журнал, 2023
Purpose: to evaluate the expediency and efficacy of conservative therapy of patients with inactive stages of Graves’ orbitopathy complicated by optical neuropathy. Materials and methods.
O. G. Panteleeva, F. H. Batyrbekova
doaj   +1 more source

Diagnostic Options in Graves' or Non‐Graves' Thyrotoxicosis: A Review for Clinical Practice

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Distinguishing Graves' disease (GD) from the other causes of thyrotoxicosis is essential for appropriate management. The clinical phenotype of GD has evolved over time and is currently more heterogenous and milder than in the past. Consequently, the differential diagnosis of thyrotoxicosis is often challenging.
Lorenzo Scappaticcio, Pierpaolo Trimboli, Paola Caruso, Chiara Porcellini, Daniela Forestiere, Maria Ida Maiorino, Katherine Esposito, Giuseppe Bellastella   +7 more
wiley   +1 more source