Results 121 to 130 of about 900,918 (272)
A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics
Andrology, EarlyView.ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis +3 more
wiley +1 more source
Thyroid papillary carcinoma arising in ectopic thyroid tissue within a second branchial cleft cyst
, 2006 Branchial cyst is the most common cyst to arise in the lateral neck, and frequently appears in the second or third decades. However, ectopic thyroid tissue within this cyst is a rare abnormality, and papillary carcinoma arising in this ectopic tissue is ...
Mustafa Cihat Avunduk +4 more
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Peri‐oesophageal metastases of pulmonary adenocarcinoma presenting as dysphagia in a dog
Australian Veterinary Journal, EarlyView.Primary pulmonary neoplasia represents approximately one percent of canine cancers. Although it is recognised that many of these cases may not display classic respiratory signs, dysphagia is not an expected presentation. This report describes a twelve‐year‐old Border Collie that presented with a history of progressive dysphagia and weight loss over ...
JM Beattie, A Teh
wiley +1 more source
Targeting KRAS for cancer therapy
British Journal of Pharmacology, EarlyView.In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia +4 more
wiley +1 more source
CD93—An emerging vascular target in cancer therapy
British Journal of Pharmacology, EarlyView.Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira +3 more
wiley +1 more source
Cancer Science, EarlyView.SLAMF6 recruits SHP‐2 to activate STAT1, upregulates CXCL10 and PD‐L1, promotes CD8+T cell infiltration, and enhances the efficacy of anti‐PD‐L1 therapy. ABSTRACT As a T‐cell receptor co‐stimulatory protein, signaling lymphocyte activation molecule family 6 (SLAMF6) is a member of the immune cell activating receptor family and is expressed on T cells ...
Yu Wu +8 more
wiley +1 more source
Submandibular solid-cystic mass as the first and sole manifestation of occult thyroid papillary carcinoma: A case report. [PDF]
World J Clin Cases, 2023 Chen GY, Li T.
europepmc +1 more source
PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub
Cancer Science, EarlyView.PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
wiley +1 more source
Advances in the Role of Chemokines in Microwave Ablation‐Based Combinatorial Immunotherapy
Cancer Science, EarlyView.MWA can initiate antitumor immunity through tumor antigen release and innate immune activation, but iMWA may instead promote an immunosuppressive microenvironment. Combining MWA with immunotherapeutic strategies offers a promising approach to enhance systemic immunity and suppress residual and distant tumors.
Ruijie An, Ningning He, Wendong Gu
wiley +1 more source
Papillary Thyroid Carcinoma Metastatic to the Frontal Sinus and Frontal Recess: Case Report
Ear, Nose & Throat JournalWe describe an extremely rare papillary thyroid carcinoma metastasic to the paranasal sinuses and our surgical management. A 39-year-old patient with a history of papillary thyroid carcinoma diagnosed five years earlier who presented with symptoms of ...
Younès Steffens MD +6 more
doaj +1 more source