Results 121 to 130 of about 84,212 (322)

An unusual presentation of longstanding atrophic Hashimoto’s thyroiditis: challenges in a resource-limited setting

open access: yesEndocrinology, Diabetes & Metabolism Case Reports
Hypothyroidism, affecting approximately 5% of the population, often remains undiagnosed, more so in developing countries. We report a 12-year-old girl with longstanding, untreated hypothyroidism who initially presented with proteinuria.
Phoebe Wamalwa, Prisca Amolo
doaj   +1 more source

Epidemiology and Genetics of Rheumatic Diseases Suggest a Constant Rate of DNA Damage as Underlying Cause

open access: yesImmunology, EarlyView.
A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley   +1 more source

Clinical manifestations and risk factors of immune-related thyroid adverse events in patients treated with PD-1 inhibitors: a case-control study

open access: yesFrontiers in Immunology
BackgroundImmune checkpoint inhibitors (ICPIs) have emerged as a powerful strategy to cancer treatment. However, while demonstrating antitumor efficacy, they can also induce a range of immune-related adverse events (irAEs).
Pengfei Zhao   +4 more
doaj   +1 more source

Prevalence of Metabolic Syndrome in Chronic Urticaria: A Systematic Review and Meta‐Analysis

open access: yes
Clinical &Experimental Allergy, EarlyView.
Daniel G. Rayner, David Gou, Wayne Sun
wiley   +1 more source

Clinical heterogeneity in vitiligo: Identification of clinical markers based patient clusters

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
Vitiligo is a chronic autoimmune disease with heterogeneous clinical presentations. This study analysed 399 patients using hierarchical clustering and identified five phenotypes based on clinical characteristics and lesion distribution. Two groups exhibited high disease activity and extensive involvement.
Laura Galissi   +8 more
wiley   +1 more source

Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management

open access: yesJournal of Internal Medicine, EarlyView.
Abstract Cryoglobulinemia (CG) is defined by the presence of serum immunoglobulins that precipitate below 37°C and redissolve upon rewarming. It is classified into three types based on immunoglobulin composition. Type I, a rare form, involves monoclonal IgM or IgG and is linked to lymphoproliferative disorders.
Anna Linda Zignego   +7 more
wiley   +1 more source

A Real-Life Study in Patients Newly Diagnosed with Autoimmune Hashimoto’s Thyroiditis: Analysis of Asthenia as Admission Complaint

open access: yesLife
Background: Amid the large panel of autoimmune thyroid diseases, Hashimoto’s thyroiditis (HT) represents a major point across multidisciplinary daily practice.
Ana Valea   +9 more
doaj   +1 more source

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