Results 201 to 210 of about 66,421 (262)

Thyrotropin binding specificity for the thyrotropin receptor

Journal of Endocrinological Investigation, 1995
Recently, highly purified bovine thyrotropin (bTSH) of pituitary origin, as well as recombinant human (h) TSH free of lutropin (LH) contamination, has been reported to activate the LH/choriogonadotropin receptor (LH/CGR). These data challenge the concept of TSH specificity for its own receptor.
Y, Nagayama, H, Yamasaki, A, Takeshita, H, Kimura, K, Ashizawa, N, Yokoyama, S, Yamashita, B, Rapoport, S, Nagataki   +8 more
openaire   +2 more sources

Thyrotropin receptor processing and interaction with thyrotropin

Biochemical and Biophysical Research Communications, 1990
In vitro transcription/translation, using rat thyrotropin receptor cDNA, results in the formation of nonglycosylated proteins able to bind thyrotropin, one of which approximates the 87 Kd size predicted for the receptor. In the presence of canine pancreatic microsomal membranes, putative glycosylation sites are modified as evidenced by digestion with ...
T, Akamizu, S, Kosugi, L D, Kohn
openaire   +2 more sources

Thyrotropin Pituitary Adenomas

World Neurosurgery, 2014
irkman et al., by reporting on their experience at National Hospital for Neurology and Neurosurgery of London K with thyrotropin (TSH)-expressing pituitary adenomas, have contributed an important and welcomed addition to the literature about pituitary tumors.
Michelangelo, de Angelis, Paolo, Cappabianca   +1 more
openaire   +2 more sources

Thyrotropin-Releasing Hormone

New England Journal of Medicine, 1982
The modern era of neuroendocrinology was ushered in just over a decade ago with the isolation and characterization, from ovine1 and porcine2 hypothalamic tissue, of a tripeptide (pyroglutamyl-histi...
openaire   +4 more sources

Thyrotropin and Thyrotropin-Releasing Hormone

1987
Pituitary thyrotropin, or thyroid-stimulating hormone (TSH), as the name implies, is the principal regulator that governs the growth and function of the thyroid gland. The secretion, metabolism, regulatory control, and actions of this important glycoprotein form the basis of this chapter.
openaire   +1 more source

Anti-Thyrotropin Autoantibodies in Patients with Macro-Thyrotropin and Long-Term Changes in Macro-Thyrotropin and Serum Thyrotropin Levels

Thyroid, 2017
Macro-thyrotropin (TSH) is a high-molecular-weight form of TSH. Most cases of macro-TSH are TSH complexed with immunoglobulin G. This study was undertaken to characterize macro-TSH.Blood samples taken from patients with subclinical hypothyroidism were screened for the presence of macro-TSH with the polyethylene glycol method and confirmed with gel ...
Naoki, Hattori, Takashi, Ishihara, Naoki, Matsuoka, Takanori, Saito, Akira, Shimatsu   +4 more
openaire   +2 more sources

Comparison of Recombinant Human Thyrotropin Receptors Versus Porcine Thyrotropin Receptors in the Thyrotropin Binding Inhibition Assay for Thyrotropin Receptor Autoantibodies

Thyroid, 1999
Thyrotropin receptor autoantibodies (TRAb) are most commonly measured in a thyrotropin-binding inhibition (TBI) assay using solubilized porcine thyrotropin receptors (pTSHR). Recently, we reported modifications in recombinant human thyrotropin receptor (hTSHR) production and extraction that made substitution of this antigen for the pTSHR practical.
A, Kakinuma, I, Morimoto, T, Kuroda, T, Fujihira, S, Eto, S M, McLachlan, B, Rapoport   +6 more
openaire   +2 more sources

The Thyrotropin Receptor

1995
This chapter has outlined the complex process required for thyroid growth and function. Both events are regulated by TSHR via a multiplicity of signals, with the aid of and requirement for a multiplicity of hormones that regulate the TSHR via receptor cross-talk: insulin, IGF-I, adrenergic receptors, and purinergic receptors.
L. D. Kohn, H. Shimura, Y. Shimura, A. Hidaka, GIULIANI, Cesidio, NAPOLITANO, Giorgio, M. Ohmori, G. Laglia, M. Saji   +8 more
openaire   +3 more sources