Results 71 to 80 of about 1,533,467 (311)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Microstructures and Electrochemical Behavior of Ti-Mo Alloys for Biomaterials

Advances in Materials Science and Engineering, 2015
The Ti alloy with 7 wt% Mo revealed a microstructure that contained only the orthorhombic α′′ phase of a fine acicular martensitic structure. The corrosion resistance of the Ti-Mo alloys increased as the Mo content increased.
Back-Sub Sung, Tae-Eon Park, Young-Hoon Yun   +2 more
doaj   +1 more source

Additive manufacturing of dense components in beta‑titanium alloys with crystallographic texture from a mixture of pure metallic element powders

Materials & Design, 2019
The fabrication of dense components composed of Ti-based alloys, i.e., Ti-X (X = Cr, Nb, Mo, Ta) alloys, from a mixture of pure elemental powders was achieved using selective laser melting (SLM) process.
Takeshi Nagase, Takao Hori, Mitsuharu Todai, Shi-Hai Sun, Takayoshi Nakano   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Microstructure, mechanical properties, and corrosion behavior of Zn-x wt.% Ti (x = 0, 0.3 and 1) alloys for biomedical applications

Journal of Materials Research and Technology
Zn-x wt.% Ti (x = 0, 0.3, and 1) alloys were developed using vacuum induction melting. The alloys were characterized using X-ray diffraction (XRD), optical microscopy, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and ...
Hany R. Ammar, S. Sivasankaran, R. Karunanithi   +2 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Oxidation and Corrosion Behavior of New Low-Cost Ti-7Fe-3Al and Ti-7Fe-5Cr Alloys from Titanium Hydride Powders

Metals, 2020
High production costs of Ti alloys usually hinders their use in industry sectors like the automotive and hence, low-cost titanium alloys could broaden titanium alloy usage. This work presents the study of three alloys— Ti-Fe, Ti-Fe-Al, and Ti-Fe-Cr&
Eduardo Reverte, Sophia A. Tsipas, Elena Gordo   +2 more
doaj   +1 more source

Grindability of Dental Cast Ti-Ag and Ti-Cu Alloys

Dental Materials Journal, 2003
Experimental Ti-Ag alloys (5, 10, and 20 mass% Ag) and Ti-Cu alloys (2, 5, and 10 mass% Cu) were cast into magnesia molds using a dental casting machine, and their grindability was investigated. At the lowest grinding speed (500 m min(-1)), there were no statistical differences among the grindability values of the titanium and titanium alloys.
Masafumi, Kikuchi, Masatoshi, Takahashi, Toru, Okabe, Osamu, Okuno   +3 more
openaire   +3 more sources

New Ti-Alloys and Surface Modifications to Improve the Mechanical Properties and the Biological Response to Orthopedic and Dental Implants: A Review

BioMed Research International, 2016
Titanium implants are widely used in the orthopedic and dentistry fields for many decades, for joint arthroplasties, spinal and maxillofacial reconstructions, and dental prostheses.
Yvoni Kirmanidou, Margarita Sidira, Maria E Drosou, V. Bennani, A. Bakopoulou, A. Tsouknidas, N. Michailidis, K. Michalakis   +7 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source