Results 111 to 120 of about 1,526,370 (261)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

A Modified Murine Calvarial Osteolysis Model Exposed to Ti Particles in Aseptic Loosening. [PDF]

open access: yesBiomed Res Int, 2020
Deng Z   +9 more
europepmc   +1 more source

Reunión del Grupo Técnico Gobierno de TI del 29 de agosto 2017

open access: yes, 2017
Presentación de la experiencia de la UV, Acuerdos y asuntos generales del grupo.Reunión del grupo técnico Gobierno de TI, durante la sesión se presentó la experiencia de la Universidad Veracruzana en el campo, además de los acuerdos y proyectos próximos ...
Miembros del Grupo Técnico Gobierno de TI
core  

The Effect of Powder Characteristics and Processing Conditions on the Microstructure and Mechanical Properties of Titanium Alloys Made by Powder Forging [PDF]

open access: yes, 2013
Powder compact forging was used to produce Ti and Ti-6Al-4V rocker arms using pre-alloyed and blended elemental powders. Green powder compacts with high relative density were manufactured by warm compaction.
Jia, Mingtu
core  

Evolution of (Ti, Mo)C particles in austenite of a Ti–Mo-bearing steel

open access: yes, 2016
The present work investigated the evolution of (Ti, Mo)C particles in austenite of a Ti-Mo-bearing steel during isothermal holding after hot deformation at 925 °C.
Guo, C.   +8 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Microstructure and mechanical property improvement of concurrent wire-powder feeding laser melting deposition Ti-6Al-4V via TiC addition

open access: yesMaterials Research Express
Wire-feed laser metal deposition (LMD-W) offers a high deposition rate and low cost, making it an effective solution for reducing costs and enhancing efficiency in manufacturing large-scale titanium aerospace components.
Chenyang Wang   +4 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

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