Results 101 to 110 of about 446 (111)

Genome-wide association study meta-analysis of suicide attempt identifies twelve genome-wide significant loci and implicates genetic risks for specific health factors [PDF]

Doherty, Anna, Hamshere, Marian, Jones, Ian, O'Donovan, Michael, Owen, Michael, Walters, James   +5 more
core   +3 more sources

Deciphering Tumor Cell Evolution in Cutaneous T-Cell Lymphomas: Distinct Differentiation Trajectories in Mycosis Fungoides and Sézary Syndrome. [PDF]

J Invest Dermatol
Jiang TT, Cao S, Kruglov O, Virmani A, Geskin LJ, Falo LD, Akilov OE.   +6 more
europepmc   +1 more source

TIAF1 and p53 Functionally Interact in Mediating Apoptosis and Silencing of TIAF1 Abolishes Nuclear Translocation of Serine 15-Phosphorylated p53

DNA and Cell Biology, 2004
TIAF1 is a TGF-beta 1-induced factor that protects L929 fibroblasts from TNF-mediated apoptosis. In contrast, overexpressed TIAF1 induces growth inhibition and apoptosis of monocytic U937 and various nonfibroblast cells. TIAF1-mediated apoptosis of U937 cells involves upregulation of p53, p21, and Smad2/4, but downregulation of ERK phosphorylation.
John Heath, Nan-Shan Chang
exaly   +4 more sources

TIAF1 Participates in the Transforming Growth Factor β1‐Mediated Growth Regulation

Annals of the New York Academy of Sciences, 2003
Abstract: TGF‐β induces growth suppression and apoptosis of various types of cells, but supports fibroblast growth. We previously isolated TIAF1 (TGF‐β1‐induced antiapoptotic factor 1), which protects murine L929 fibroblasts from TNF cytotoxicity. Here, we show that TIAF1 induced growth inhibition and apoptosis of monocytic U937 and other types of ...
Nan-Shan Chang
exaly   +4 more sources

Cloning and Characterization of a Novel Transforming Growth Factor-β1-Induced TIAF1 Protein That Inhibits Tumor Necrosis Factor Cytotoxicity

Biochemical and Biophysical Research Communications, 1998
To determine how TGF-beta1 protects L929 fibroblasts against TNF-alpha cytotoxicity, we report the isolation and characterization of a novel cDNA encoding a 12-kDa TGF-beta1-induced antiapoptotic factor, designated TIAF1. GFP-tagged TIAF1 protein is present mostly in perinuclear and nuclear locations.
Nan-Shan Chang
exaly   +4 more sources

Abstract 3974: TIAF1 blocks p53 suppression of SMAD promoter activation

Cancer Research, 2010
Abstract p53 participates in the TGF-β signaling. How p53 regulates SMAD gene transcription is largely unknown. TIAF1 is a TGF-β1-induced factor and a downstream effector of the TGF-β signaling. TIAF1 is known to control nuclear localization of Ser15-phosphorylated p53.
Nan‐Shan Chang, Li‐Jin Hsu, Ming‐Hui Lee, Sing‐Ru Lin   +3 more
openalex   +2 more sources

TGF-β1 signals TIAF1 self-association, amyloid superinduction and apoptosis

Cytokine, 2009
Nan‐Shan Chang
openalex   +2 more sources

p53-WWOX-TIAF1為腫瘤抑制軸心

, 2012
周沛宜, Pei‐Yi Chou
openalex   +1 more source

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Weighted burden analysis of exome‐sequenced late‐onset Alzheimer's cases and controls provides further evidence for a role for PSEN1 and suggests involvement of the PI3K/Akt/GSK‐3β and WNT signalling pathways

Annals of Human Genetics, 2020
David Curtis
exaly  

Functional antagonism between p53 and WWOX in vivo leads to protein aggregation in the brain

FASEB Journal, 2020
Nan-Shan Chang
exaly