Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance
Medicinal Research Reviews, EarlyView.ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi +4 more
wiley +1 more source
Attitudes Toward Prenatal Interventions in the Fanconi Anemia Community
Prenatal Diagnosis, EarlyView.ABSTRACT Objective In‐utero cell and gene therapies may offer prenatal treatment options for inherited diseases. Preclinical data suggests in‐utero (IU) hematopoietic stem cell transplantation (HSCT) could prevent Fanconi anemia (FA) related bone marrow failure without genotoxic conditioning or immune suppression.
Tony Lum +4 more
wiley +1 more source
Molecular surveillance reveals a potential hotspot of tick-borne disease in Yakeshi City, Inner Mongolia. [PDF]
BMC Microbiol, 2023 Tian J +6 more
europepmc +1 more source
Assessment of insecticide use practices in licensed pest control operators in North Carolina
Pest Management Science, EarlyView.A statewide survey of 105 licensed North Carolina pesticide operators found ants, mosquitoes, and aphids as top target pests, pyrethroids as the dominant insecticide class (68%), and limited resistance monitoring, establishing a baseline for future insecticide resistance management and outreach.
Kaylin Russell +3 more
wiley +1 more source
From Tick to Test: A Comprehensive Review of Tick-Borne Disease Diagnostics and Surveillance Methods in the United States. [PDF]
Life (Basel), 2023 Rowan S +5 more
europepmc +1 more source
Camels as a Climate‐Resilient Linchpin for Sustainable Development in Global Drylands
Sustainable Development, EarlyView.ABSTRACT Camels represent a significant, yet underutilized, asset for advancing integrated sustainable development in the world's expanding drylands. Previous reviews have examined camels' physiology, milk composition, or pastoral systems in isolation; this review examines their potential as a climate‐resilient linchpin for food systems by synthesizing
Ayana Angassa +2 more
wiley +1 more source
Chemical and Biological Determinants of PEG‐Lipid Shedding From Therapeutic Nanoparticles
Small, EarlyView.PEG‐lipids play a central role in governing lipid nanoparticle stability, targeting, and function. However, PEG‐lipids can “shed” from the nanoparticle surface in biological environments, with the extent and kinetics of shedding influenced by chemical and biological factors.
Ethan P. Cisneros +2 more
wiley +1 more source
Improving Surveillance of Human Tick-Borne Disease Risks: Spatial Analysis Using Multimodal Databases. [PDF]
JMIR Public Health Surveill, 2023 Maxwell SP +5 more
europepmc +1 more source
Smart Molecules, EarlyView.The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang +8 more
wiley +1 more source
Increasing Risk of Tick-Borne Disease through Growth Stages in Ticks. [PDF]
Clin Pract, 2023 Kondo M +5 more
europepmc +1 more source