Results 91 to 100 of about 31,240 (214)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Recent Advances in Cryogel Applications for Musculoskeleatal Regeneration

Medicinal Research Reviews, EarlyView.
ABSTRACT Hydrogels have been widely used in tissue engineering due to their high‐water content and biocompatibility, yet their densely cross‐linked microstructure inherently limits cell infiltration, mass transport, and mechanical support. Cryogels, formed through partial freezing and crosslinking under subzero conditions, provide unique 3D macroporous
Dohee Kim, Shinwon Kang, Hyejin Jo, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Molecular surveillance reveals a potential hotspot of tick-borne disease in Yakeshi City, Inner Mongolia. [PDF]

BMC Microbiol, 2023
Tian J, Liu J, Zhao H, Chen X, Geng X, Lu M, Li K.   +6 more
europepmc   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

Performance of the French national hospital discharge database algorithm to identify hospitalised Lyme borreliosis cases, France, 2017–2018

BMC Infectious Diseases
Background In France, surveillance of Lyme borreliosis (LB) is based on general practitioners of a sentinel network and the national hospital discharge database (PMSI). Given the known limitations of the PMSI for epidemiological surveillance, we assessed
Alexandra Septfons, Leslie Grammatico-Guillon, Jean Capsec, Christophe Garborit, Adrien Lemaignen, Philippe Lanotte, Solène Patrat Delon, Pierre Tattevin, Alexandre Scanff, Florian Bouchet-Crivat, Brigitte Degeilh, Yves Hansmann, Claire Sauvage, Amandine Woerly, Benoit Jaulhac, Thierry Blanchon, Alice Raffetin, Julie Figoni, Jean Claude Desenclos, Henriette De Valk   +19 more
doaj   +1 more source

From Tick to Test: A Comprehensive Review of Tick-Borne Disease Diagnostics and Surveillance Methods in the United States. [PDF]

Life (Basel), 2023
Rowan S, Mohseni N, Chang M, Burger H, Peters M, Mir S.   +5 more
europepmc   +1 more source

The magnitude and economic replacement value of wild meat obtained from ‘recreational’ big game hunting in the United States

People and Nature, EarlyView.
Abstract Meat production has notable benefits for food security, nutrition and various production economies, but has elicited substantial negative environmental impacts. Recreational hunting provides an alternative to agricultural meat production for over 24 million hunters worldwide.
Shane P. Mahoney, Richard D. Honor
wiley   +1 more source

Attitudes Toward Prenatal Interventions in the Fanconi Anemia Community

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective In‐utero cell and gene therapies may offer prenatal treatment options for inherited diseases. Preclinical data suggests in‐utero (IU) hematopoietic stem cell transplantation (HSCT) could prevent Fanconi anemia (FA) related bone marrow failure without genotoxic conditioning or immune suppression.
Tony Lum, Catherine Lee, Tippi MacKenzie, Billie Lianoglou, Agnieszka Czechowicz   +4 more
wiley   +1 more source

Improving Surveillance of Human Tick-Borne Disease Risks: Spatial Analysis Using Multimodal Databases. [PDF]

JMIR Public Health Surveill, 2023
Maxwell SP, Brooks C, Kim D, McNeely CL, Cho S, Thomas KC.   +5 more
europepmc   +1 more source

DEET‐cyclodextrin inclusion complexes for mosquito and tick repellency: Extended repellency time and no zebrafish embryotoxicity

Pest Management Science, EarlyView.
Hydroxypropyl‐β‐cyclodextrin (HPβCD)–N,N‐diethyl‐meta‐toluamide (DEET) complex extended tick repellency to 168 h. Full protection against Aedes aegypti for 7 h with HPβCD‐DEET. HPβCD reduced DEET release and skin retention significantly. No embryotoxicity observed below 325 mg L−1 in zebrafish model.
Gessyka Rayana Silva Pereira, Gleidson Cardoso, Maria Luiza Kuhn Camargo, Michele Resende Machado, Mayara Macedo Barrozo, Juscelino Rodrigues, Gisele Augusto Rodrigues de Oliveira, Caio Monteiro, Christian Luz, Ricardo Neves Marreto, Stephânia Fleury Taveira   +10 more
wiley   +1 more source