Results 81 to 90 of about 69,379 (294)

Total Chemical Synthesis of Interleukin‐15 and Interleukin‐2: Taming Protein Hydrophobicity and Aggregation by a Versatile Solubilizing Strategy

Angewandte Chemie, EarlyView.
A reducible solubilizing tag strategy (RST‐2.0) enables the synthesis, purification and ligation of difficult peptides while being readily removable just during folding, which overcomes the common challenges from protein hydrophobicity and aggregation. With this method, we achieved the first total synthesis of native and N‐glycosylated IL‐15 as well as
Jingwen Zeng, Haiyan Zhou, Wang Xia, Hongxiang Wu, Xuechen Li   +4 more
wiley   +2 more sources

Tick-borne encephalitis (TBE) [PDF]

Tick-borne encephalitis, or TBE, is a human viral infectious disease involving the central nervous system. TBE is caused by the tick- borne encephalitis virus (TBEV), a member of the family Flaviviridae, and was initially isolated in 1937.

core  

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

AND‐Logic‐Gated Aptamer Switch for Precise Targeting and Regulation of RNA G‐Quadruplexes

Angewandte Chemie, EarlyView.
An AND‐logic‐gated aptamer switch enables tumor‐selective activation of RNA G‐quadruplex (rG4)‐targeting function. By combining cell‐surface recognition and intracellular redox sensing, the system achieves precise regulation of disease‐relevant RNA structures exclusively in tumor cells, with minimal off‐target effects in normal cells, offering a ...
Dan Wang, Ying Feng, Chun Kit Kwok
wiley   +2 more sources

What Stage Are We at in the Development of Vaccines Against Tick-Borne Diseases?

Vaccines
The increasing prevalence of Lyme disease, tick-borne encephalitis (TBE), and other tick-borne infections such as Babesia, Ehrlichia, Rickettsia, and Anaplasma is a growing public health concern. Existing tick bite prevention strategies are insufficient;
Weronika Stachera, Magdalena Szuba, Arya Taesung Kim, Subin Yu, Jaeuk Choi, Deborah Nzekea, Yen Ching Wu, Adrianna Brzozowska, Marcin Sota, Marianna Misiak, Monika Dybicz   +10 more
doaj   +1 more source

Tick-borne pathogens and the vector potential of ticks in China

Parasites & Vectors, 2015
Ticks, as obligate blood-sucking ectoparasites, attack a broad range of vertebrates and transmit a great diversity of pathogenic microorganisms. They are considered second only to mosquitoes as vectors of human disease, and the most important vector of ...
Zhijun Yu, Hui Wang, Tianhong Wang, Wenying Sun, Xiaolong Yang, Jingze Liu   +5 more
doaj   +1 more source

Tick borne encephalitis in EU

, 2011
Tick borne encephalitis is emerging in several european countries. Prevention of new cases and mitigation of the risk for the european citizens should be based on a precise estimate of the burden of the disease at Eu level and temporal variation in ...
Rizzoli, Annapaola
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Mastication‐Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy

Advanced Science, EarlyView.
This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng, Jing‐Rong Cheng, Yu Qin, Jie Lei, Chen‐Chen Gao, Hong‐Ying Fu, Li‐Ping Wu, Thanh D. Nguyen, Xu‐Liang Deng, Kai‐Yuan Fu, Yang Liu   +10 more
wiley   +1 more source

Clinical and epidemiological features of tick-borne encephalitis in adults in Novosibirsk in 2014-2023

Лечащий Врач
Background. Fundamental differences in the scale, overall picture of tick-borne encephalitis, the structure and quality of its clinical variants determine the need for regular analytical work and competent dynamic accounting of clinical, epidemiological ...
Yu. V. Kazakova, Ya. S. Ulyanova, E. I. Krasnova, T. G. Burmistrova, V. G. Kuznetsova, E. N. Usolkina, V. V. Provorova, P. N. Verchenko, P. D. Urusova   +8 more
doaj   +1 more source

Assessing the impact of climate change on vector-borne viruses in the EU through the elicitation of expert opinion

, 2010
Expert opinion was elicited to undertake a qualitative risk assessment to estimate the current and future risks to the European Union (EU) from five vector-borne viruses listed by the World Organization for Animal Health.
Gale, P.F., Kosmider, R., Ramnial, V., EPIZONE (Funder), Brouwer, A., Fooks, A.R., Kelly, L., , EPIZONE (Funder), Gale, P., Kosmider, R.D., Snary, E.L.   +10 more
core   +1 more source