Results 61 to 70 of about 32,391 (255)
Advanced Science, EarlyView.Peptide‐inspired associative polymers with arginine‐like guanidinium stickers and lysine‐like ammonium spacers undergo chain collapse and liquid‐liquid phase separation induced by reversible sticker associations. Sticker valence and tunable association strength jointly control the phase behavior, chain conformation, and interfacial cohesion of these ...
Seung‐Hwan Oh +7 more
wiley +1 more source
Advanced Science, EarlyView.Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin +14 more
wiley +1 more source
Microorganisms, 2020 Over 600,000 vector-borne disease cases were reported in the United States (U.S.) in the past 13 years, of which more than three-quarters were tick-borne diseases.
Brenden G. Tully, Jason F. Huntley
doaj +1 more source
Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation
Advanced Science, EarlyView.Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu +8 more
wiley +1 more source
Advanced Science, EarlyView.A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li +9 more
wiley +1 more source
Проблемы особо опасных инфекцийThe aim of the work was to compare the main socio-demographic and eco-epidemiological parameters of tick-borne viral encephalitis, tick-borne borrelioses and tick-borne rickettsiosis.Materials and methods.
O. V. Mel’nikova +3 more
doaj +1 more source
Luciferase activity changes during the acute period of tick-borne mixed infection in children
Бюллетень сибирской медицины, 2008 The research of clinical characteristics of different tick mixed infections etiological variants in children — tick-borne encephalitis, ixodid tick-borne borreliosis, granulocytic anaplasmosis and monocytic ehrlichiosis in human in Kemerovo region showed
O. S. Pinevich +4 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu +10 more
wiley +1 more source
Tick-borne pathogens and the vector potential of ticks in China
Parasites & Vectors, 2015 Ticks, as obligate blood-sucking ectoparasites, attack a broad range of vertebrates and transmit a great diversity of pathogenic microorganisms. They are considered second only to mosquitoes as vectors of human disease, and the most important vector of ...
Zhijun Yu +5 more
doaj +1 more source