Results 51 to 60 of about 31,240 (214)
Advanced Science, EarlyView.Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang +8 more
wiley +1 more source
Проблемы особо опасных инфекцийThe aim of the work was to compare the main socio-demographic and eco-epidemiological parameters of tick-borne viral encephalitis, tick-borne borrelioses and tick-borne rickettsiosis.Materials and methods.
O. V. Mel’nikova +3 more
doaj +1 more source
Luciferase activity changes during the acute period of tick-borne mixed infection in children
Бюллетень сибирской медицины, 2008 The research of clinical characteristics of different tick mixed infections etiological variants in children — tick-borne encephalitis, ixodid tick-borne borreliosis, granulocytic anaplasmosis and monocytic ehrlichiosis in human in Kemerovo region showed
O. S. Pinevich +4 more
doaj +1 more source
Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma
Advanced Science, EarlyView.ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba +25 more
wiley +1 more source
Tick-borne pathogens and the vector potential of ticks in China
Parasites & Vectors, 2015 Ticks, as obligate blood-sucking ectoparasites, attack a broad range of vertebrates and transmit a great diversity of pathogenic microorganisms. They are considered second only to mosquitoes as vectors of human disease, and the most important vector of ...
Zhijun Yu +5 more
doaj +1 more source
Advanced Science, EarlyView.A flexible pressure sensor with triple‐gradient design of conductivity, modulus, and dimension in binary micro‐dome pixels is proposed. Based on precisely‐designed CNT/PDMS matrix, the device exhibits a linear sensitivity of 974.1 kPa−1 across range up to 1.8 MPa (R2 > 0.99), offering an effective strategy for potential applications in healthcare ...
Yifan Liu +9 more
wiley +1 more source
What Stage Are We at in the Development of Vaccines Against Tick-Borne Diseases?
VaccinesThe increasing prevalence of Lyme disease, tick-borne encephalitis (TBE), and other tick-borne infections such as Babesia, Ehrlichia, Rickettsia, and Anaplasma is a growing public health concern. Existing tick bite prevention strategies are insufficient;
Weronika Stachera +10 more
doaj +1 more source
Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform
Advanced Science, EarlyView.Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao +10 more
wiley +1 more source
Generalizable Strategies for the Synthesis of Cereblon‐Recruiting PROTAC Prodrugs
Angewandte Chemie, EarlyView.Cereblon‐recruiting PROTACs remain challenging to derivatize for prodrug‐based delivery. In this study, three complementary conjugation strategies enabled the efficient synthesis of cleavable PROTAC prodrugs with tunable release kinetics that can be incorporated into a library of PEGylated constructs and bottlebrush prodrugs.
Aiden X. Wang +7 more
wiley +2 more sources