Results 131 to 140 of about 180,121 (375)

Hsa_circ_0026782 Acts as a “Molecular Break” of CREB1‐Mediated Transcription by Promoting Its Phosphorylation at Ser142 That Prevents Keloid Progression

Advanced Science, EarlyView.
Model for the role of hsa_circ_0026782/p‐CREB1 (Ser142) played in keloid. Hsa_circ_0026782 is derived from back‐splicing of ITGA7 exon 4. When hsa_circ_0026782 binds to CREB1, the exposure of the bZIP domain and dimerization of CREB1 are promoted (upper left).
Xin‐Cao Zhong, Chun‐Ye Chen, Zi‐Xuan Feng, Yong Wang, Tao Zhang, Ze‐Ming Zhuang, Zhang‐Rui Wu, Yong‐Zhong Du, Jun Chen, Xiao‐Ying Lin, Wei‐Qiang Tan   +10 more
wiley   +1 more source

EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib‐Resistant Lung Cancer Therapy

Advanced Science, EarlyView.
In this study, an EGFR lipoSM PROTACs (GM‐protac), which can achieve efficient EGFR degradation and HDACi delivery, is developed. It is found that GM‐protac can both block EGFR‐dependent pathways and bypass the HDAC signaling pathway. Meanwhile, both display obvious tumor inhibition with negligible toxicity in EGFR‐TKI‐resistant lung cancer animal ...
Dongyuan Wang, Yajing Liu, Ying Chen, Chuan Dai, Wenzhu Hu, Jinyan Han, Zigang Li, Feng Yin, Yu Zhang, Chen Shi   +9 more
wiley   +1 more source

Unveiling Novel Viral Diversity, Biogeography, and Host Networks in Wildlife Through High‐Throughput Sequencing Data Mining

Advanced Science, EarlyView.
Analysis of 57 536 high‐throughput sequencing datasets uncovers a vast, hidden world of viruses in wildlife. The researchers reveal significant geographic and host‐specific patterns of viruses, and their surprising cross‐species transmissions, such as avian flu viruses infecting goats.
Hai Wang, Yafei Meng, Xiaoyuan Chen, Xinyuan Cui, Qian Zuo, Na Han, Xianghui Liang, Xuejuan Shen, Caiwu Li, Desheng Li, Fumin Wang, Liangping He, Rujian Chen, Xingbang Lu, Wenjie You, Aiping Wu, Rui‐Ai Chen, Wu Chen, Chan Ding, Yongyi Shen   +19 more
wiley   +1 more source

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels

Advanced Science, EarlyView.
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu, Zhihao Xu, Yilun Tong, Changtai Wang, Yueqi Yao, Yujie Diao, Jingyuan Ma, Shijun Zhou, Yinan Du, Zhenhua Zhang, Gang Xu   +10 more
wiley   +1 more source

Modular Synthesis of Pyritide‐Inspired Macrocycles Featuring Bipyridine Motifs

Angewandte Chemie, EarlyView.
A pyritide‐inspired build/couple/pair strategy yields a diverse macrocycle library. This approach expands chemical space and enables the discovery of 6paW, a potent anti‐ferroptotic agent. Abstract Macrocycles represent a promising class of drug‐like scaffolds with unique structural features and the ability to engage challenging targets such as protein–
Ji Hyae Lee, Sihyeong Yi, Juhyun Bang, Hyun Choi, Seung Bum Park   +4 more
wiley   +2 more sources

Molecular surveillance of Theileria parasites of livestock in Oman [PDF]

, 2017
Background: Theileriosis is one of the most prevalent infectious diseases of livestock in the Arabian Peninsula, and causes high rates of mortality and morbidity in sheep and cattle.
Al-Fahdi, Amira, Al-Hamidhi, Salama, Alqamashoui, Badar, Babiker, Hamza, Bilgic, Huseyin Bilgin, Bobade, Patrick, Hussain, Abdel-Rahim, Johnson, Eugene H., Karagenc, Tulin, Kose, Onur, Shiels, Brian, Tageldin, Mohammed H., Tait, Andy   +12 more
core   +1 more source

Economic downturn results in tick-borne disease upsurge

Parasites & Vectors, 2011
BackgroundThe emergence of zoonoses is due both to changes in human activities and to changes in their natural wildlife cycles. One of the most significant vector-borne zoonoses in Europe, tick-borne encephalitis (TBE), doubled in incidence in 1993 ...
Elinor R Godfrey, S. Randolph
semanticscholar   +1 more source

Presence of Borrelia, Rickettsia, and Ehrlichia in Field-collected Ticks on Candlers Mountain, Virginia [PDF]

, 2016
Tick survey is an important factor in the determination of tick-borne disease in an area. A tick survey was done on Candlers Mountain in Lynchburg, Virginia, to look for the presence of Borrelia, Rickettsia, and Ehrlichia. With the help of CO2 traps, 116
Colombo, Lara E
core  

Association between canine leishmaniosis and Ehrlichia canis co-infection: a prospective case-control study [PDF]

, 2018
Background In the Mediterranean basin, Leishmania infantum is a major cause of disease in dogs, which are frequently co-infected with other vector-borne pathogens (VBP).
A Mazeris, A Saha, A Sainz, AS De Tommasi, C Attipa, C Attipa, C Maia, CB Cardinot, CF Alves, Charalampos Attipa, Chris Helps, CL Barbieri, CLA Ehrlichiosis, D Chochlakis, D Otranto, D Otranto, David Morris, Francesca Soutter, G Baneth, G Baneth, J Alvar, J Franca-Costa, J Le Gal, J Moreno, K Katherine, Kostas Papasouliotis, L Cortese, L Cortese, L Solano-Gallego, L Solano-Gallego, Laia Solano-Gallego, M Novacco, M Olivier, M-D Tabar, MG Vrhovec, MJ Day, MJ Grigg, P Parola, P Seneviratna, R Killick-Kendrick, RB Kline, RJ Quinnell, RN Davidson, S Carver, S Davies, S Harrus, S Harrus, S Tasker, Scott Carver, SE Shaw, Séverine Tasker, T Bouzouraa, V Pintado, WH Pryor Jr, Y Mekuzas, Y Rosseel   +55 more
core   +5 more sources

Micro/Nanorobots for Combating Brain Disorders: Challenges, Advances, and Perspectives

Advanced Science, EarlyView.
Micro/nanorobots (MNRs) offer a transformative approach for precision therapy in brain disorders. By overcoming biological barriers and enabling controlled propulsion, targeted delivery, and real‐time imaging/tracking, MNRs pave the way toward effective, minimally invasive treatments. This review outlines the interplay between brain disease challenges,
Qi Zhang, Dong Sun
wiley   +1 more source