Results 81 to 90 of about 44,700 (260)

Polymicrobial Nature of Tick-Borne Diseases

mBio, 2019
Tick-borne diseases have increased in prevalence in the United States and abroad. The reasons for these increases are multifactorial, but climate change is likely to be a major factor. One of the main features of the increase is the geographic expansion of tick vectors, notably Amblyomma americanum , which has ...
James L. Coleman, Jorge L. Benach, Teresa Tagliafierro, Santiago Sanchez-Vicente, Rafal Tokarz   +4 more
openaire   +3 more sources

Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD‐ADRD): Executive summary of recommendations for primary care

Alzheimer's &Dementia, EarlyView.
Abstract US clinical practice guidelines for the diagnostic evaluation of cognitive impairment due to Alzheimer's disease (AD) or AD and related dementias (ADRD) are decades old and aimed at specialists. This evidence‐based guideline was developed to empower all—including primary care—clinicians to implement a structured approach for evaluating a ...
Alireza Atri, Bradford C. Dickerson, Carolyn Clevenger, Jason Karlawish, David Knopman, Pei‐Jung Lin, Mary Norman, Chiadi Onyike, Mary Sano, Susan Scanland, Maria Carrillo   +10 more
wiley   +1 more source

Increasing the Discovery Power and Confidence Levels of Disease Association Studies: A Survey [PDF]

arXiv, 2017
The majority of common diseases are influenced by multiple genetic and environmental factors such as Cancer. Even though uncovering the main causes of disease is deemed difficult due to the complexity of gene-gene and gene-environment interactions, major research efforts aim at identifying disease risk factors, especially genetic ones.
arxiv  

The development of nations conditions the disease space [PDF]

arXiv, 2019
Using the economic complexity methodology on data for disease prevalence in 195 countries during the period of 1990-2016, we propose two new metrics for quantifying the relatedness between diseases, or the `disease space' of countries. With these metrics, we analyze the geography of diseases and empirically investigate the effect of economic ...
arxiv  

Proteomic as an Exploratory Approach to Develop Vaccines Against Tick-Borne Diseases Using Lyme Borreliosis as a Test Case

Vaccines, 2020
Tick-borne diseases affecting humans and animals are on the rise worldwide. Vaccines constitute an effective control measure, but very few are available. We selected Lyme borreliosis, a bacterial infection transmitted by the hard tick Ixodes, to validate
Emilie Talagrand-Reboul, Benoit Westermann, Matthieu A. Raess, Gilles Schnell, Paola Cantero, Cathy Barthel, Laurence Ehret-Sabatier, Benoit Jaulhac, Nathalie Boulanger   +8 more
doaj   +1 more source

Breaking barriers: Smart vaccine platforms for cancer immunomodulation

Cancer Communications, EarlyView.
Abstract Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need to explore alternative approaches such as cancer vaccines. Leveraging the immune system's natural ability to target and kill cancer cells holds great therapeutic potential ...
Mohammad Mahmoudi Gomari, Taha Ghantabpour, Nima Pourgholam, Neda Rostami, Stephen M. Hatfield, Farzaneh Namazifar, Shadi Abkhiz, Seyed Sadegh Eslami, Mahsa Ramezanpour, Mahsa Darestanifarahani, Igor Astsaturov, Sidi A. Bencherif    +11 more
wiley   +1 more source

Profiling Serine Hydrolases in the Leishmania Host‐Pathogen Interactome Using Cell‐Permeable Activity‐Based Fluorophosphonate Probes

ChemBioChem, Accepted Article.
Leishmaniasis, a vector borne neglected tropical disease, caused by the protozoan parasite Leishmania, is a major global public health challenge with millions of new cases annually. Treatment of leishmaniasis is difficult for many reasons including a multiple life‐cycle stages, involving both an infective insect vector form, the promastigote, and a ...
Jaime A. Isern, Exequiel O.J. Porta, Karunakaran Kalesh, Zisis Koutsogiannis, Davide Cazzola, Ehmke Pohl, Paul Denny, Patrick G. Steel   +7 more
wiley   +1 more source

Classification and Prediction of Heart Diseases using Machine Learning Algorithms [PDF]

Heart disease is a serious worldwide health issue because it claims the lives of many people who might have been treated if the disease had been identified earlier. The leading cause of death in the world is cardiovascular disease, usually referred to as heart disease.
arxiv   +1 more source

Tick related diseases in Switzerland, 2008 to 2011

Swiss Medical Weekly, 2012
QUESTION UNDER STUDY: To determine the incidence and determinants of tick related diseases in Switzerland, such as tick bites and Lyme borreliosis in primary care and tick borne encephalitis.
Ekkehardt Altpeter, Hanspeter Zimmermann, Jürgen Oberreich, Olivier Péter, Charles Dvořák, Swiss Sentinel Surveillance Network   +5 more
doaj   +1 more source

Click‐Functionalized Cyanine Fluorogenic Dimers for Improved Detection of GPCRs: Application to imaging of ApelinR in Living Cells

Chemistry – A European Journal, Accepted Article.
Fluorogenic dimers enable background‐free imaging of biological targets under wash‐free conditions owing to a strong fluorescence enhancement in the apolar cell microenvironment. However, it is crucial that the imaging probe interacts solely with the target receptor to avoid non‐specific interactions and ensure detection with a high signal‐to‐noise ...
Océane Florès, Yann Berthomé, Lucille Weiss, Sarah Griesbaum-Dubourg, Stéphanie Riché, Patrick Wagner, Christel Valencia, Pascal Villa, Andrey S. Klymchenko, Julie Karpenko, Dominique Bonnet   +10 more
wiley   +1 more source