Results 21 to 30 of about 19,735 (198)

Effective Methods of Estimation of Pathogen Prevalence in Pooled Ticks

open access: yesPathogens, 2023
Since tick-borne diseases (TBDs) incidence, both in human and animal populations, is increasing worldwide, there is the need to assess the presence, distribution and prevalence of tick-borne pathogens.
Gerardo Fracasso   +5 more
doaj   +1 more source

The role of companion animals in the environmental circulation of tick-borne bacterial pathogens

open access: yesAnnals of Agricultural and Environmental Medicine, 2018
Ticks are known as vectors of a wide range of pathogens of medical and veterinary importance; some of them of zoonotic concern constitute a hazard for the emergence of tick-borne diseases shared between humans and domestic animals and becoming a part of ...
Bogumiła Skotarczak
doaj   +1 more source

No molecular detection of tick-borne pathogens in the blood of patients with erythema migrans in Belgium

open access: yesParasites & Vectors, 2022
Background A number of tick-borne pathogens circulate in the Belgian tick population in addition to the causative agent of Lyme borreliosis. However, so far, only a few patients with tick-borne diseases other than Lyme borreliosis have been reported in ...
Laurence Geebelen   +8 more
doaj   +1 more source

Advances in the Study of the Tick Cattle Microbiota and the Influence on Vectorial Capacity

open access: yesFrontiers in Veterinary Science, 2021
The information from the tick cattle microbiota suggests that the microbial populations may modulate a successful infection process of the tick-borne pathogens. Therefore, there is a need to know the microbial population and their interactions.
Hugo Aguilar-Díaz   +4 more
doaj   +1 more source

Tick-borne pathogens and the vector potential of ticks in China

open access: yesParasites & Vectors, 2015
Ticks, as obligate blood-sucking ectoparasites, attack a broad range of vertebrates and transmit a great diversity of pathogenic microorganisms. They are considered second only to mosquitoes as vectors of human disease, and the most important vector of ...
Zhijun Yu   +5 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Toward Multi(radio)metalated DNA: Enzymatic Polymerization of Metal‐Chelate‐Modified Deoxyribonucleoside Triphosphates

open access: yesAngewandte Chemie, EarlyView.
This work presents the first enzymatic polymerization of defined metal‐chelator‐modified nucleotides that leverage polymerase fidelity for uniform (radio)metal loading with successful incorporation of five different metals: Ga, In, Tb, Lu, and Y.
Antonio A. W. L. Wong   +2 more
wiley   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Chemically Regulated STING‐Activating Prodrugs of Deoxyribose Cyclic Dinucleotides Elicit Robust Immune Activation and Durable Antitumor Immunity

open access: yesAngewandte Chemie, EarlyView.
All three diastereoisomers of an esterase‐sensitive phosphotriester dCDN prodrug demonstrate improved activity. The (Rp,Rp) diastereoisomer shows the highest activity with an EC50 of 1.7 nM in STING activation and displays the most pronounced antitumor activity via intravenous administration, significantly suppressing tumor proliferation, extending the
Zhiqiang Xie   +14 more
wiley   +2 more sources

Linking tick and wildlife host distributions to map risk of tick-borne diseases

open access: yesParasites & Vectors
Background Tick-borne pathogens threaten livestock worldwide, causing diseases such as anaplasmosis, babesiosis, heartwater and theileriosis in cattle. The epidemiology of each disease is complex, with multiple tick and/or host species interacting across
José-María García-Carrasco   +5 more
doaj   +1 more source

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