Results 41 to 50 of about 19,735 (198)
PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression
Advanced Science, EarlyView.Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian +13 more
wiley +1 more source
Survey of ticks and tick-borne pathogens in wild chimpanzee habitat in Western Uganda
Parasites & Vectors, 2023 Background Ticks and tick-borne pathogens significantly impact both human and animal health and therefore are of major concern to the scientific community. Knowledge of tick-borne pathogens is crucial for prescription of mitigation measures.
Camille Lacroux +10 more
doaj +1 more source
Advanced Science, EarlyView.Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun +6 more
wiley +1 more source
Advanced Science, EarlyView.Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao +19 more
wiley +1 more source
Tropical Medicine and Infectious DiseaseTicks are vectors of public health concern because the pathogens they transmit can cause detrimental diseases in humans. Lyme disease, tick-borne relapsing fever, human granulocytic anaplasmosis, Rocky Mountain spotted fever, tick-borne encephalitis ...
Michael W. Curtis, Job E. Lopez
doaj +1 more source
Interrupted Blood Feeding in Ticks: Causes and Consequences
Microorganisms, 2020 Ticks are obligate hematophagous arthropods and act as vectors for a great variety of pathogens, including viruses, bacteria, protozoa, and helminths. Some tick-borne viruses, such as Powassan virus and tick-borne encephalitis virus, are transmissible ...
Djamel Tahir +8 more
doaj +1 more source
Tropical Medicine and Infectious DiseaseTick-borne diseases have emerged as a major global public health problem in recent decades. The increasing incidence and geographical dissemination of these diseases requires the implementation of robust surveillance systems to monitor their prevalence ...
Raúl Contreras-Ferro +13 more
doaj +1 more source
Detection of tick-borne pathogens in blood-fed ticks from animals across nine Asian countries
Microbiology SpectrumClimate change, land development, and increased outdoor human activity have increased the prevalence and distribution of tick-borne pathogens, causing public health issues.
Hye-Ryung Byun +17 more
doaj +1 more source
BACTERIAL AND VIRAL PATHOGENS IN IXODES SP. TICKS IN ST. PETERSBURG AND LENINGRAD DISTRICT
Инфекция и иммунитет, 2018 Tick-borne infections are the most common group of zooanthroponotic diseases in the Northern Hemisphere. For the Baltic Sea region and Fennoscandia, the dominant infectious pathologies transmitted by ticks are tick-borne borreliosis and tick- borne ...
Yu. A. Panferova +3 more
doaj +1 more source