Results 61 to 70 of about 19,735 (198)

Bioresponsive pseudoGlucosinolates (psGSLs) Release Isothiocyanates (ITCs) in the Presence of Nitroreductases

Chemistry – A European Journal, EarlyView.
This work introduces the concept of pseudoglucosinolates (psGSLs) and reports the synthesis and evaluation of nitroreductase‐responsive psGSLs. These compounds represent a complementary prodrug strategy to natural glucosinolates (GSLs) for the controlled release of isothiocyanates (ITCs), enabling bio‐responsive protein labeling, as demonstrated in ...
Claire C. Jimidar, Charity S. G. Ganskow, Mervic D. Kagho, Aishi Chakrabarti, Lorenz Wiese, Michael Zollo, Ulrike Beutling, Leona C. Cesar, Julia Morud, Kamila Bugaj, Mark Brönstrup, Stephan A. Sieber, Stephan M. Hacker, Philipp Klahn   +13 more
wiley   +1 more source

Unlocking the Multifunctional Properties of Litsea cubeba Essential Oil: Composition, Antimicrobial, Antibiofilm and Insecticidal Activities

Flavour and Fragrance Journal, EarlyView.
Unveiling the chemical and biological properties of Litsea cubeba essential oil. ABSTRACT Litsea cubeba essential oil (LCEO) is recognised for its broad spectrum of biological activities, including antimicrobial and insecticidal effects, making it a promising natural alternative to synthetic agents.
Miroslava Kačániová, Minhang Qiao, Alessandro Bianchi, Joel Horacio Elizondo‐Luevano, Anis Ben Hsouna, Rania Ben Saad, Zhaojun Ban, Li Li, Jian Lou, Wissem Mnif, Stefania Garzoli   +10 more
wiley   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

DEET‐cyclodextrin inclusion complexes for mosquito and tick repellency: Extended repellency time and no zebrafish embryotoxicity

Pest Management Science, EarlyView.
Hydroxypropyl‐β‐cyclodextrin (HPβCD)–N,N‐diethyl‐meta‐toluamide (DEET) complex extended tick repellency to 168 h. Full protection against Aedes aegypti for 7 h with HPβCD‐DEET. HPβCD reduced DEET release and skin retention significantly. No embryotoxicity observed below 325 mg L−1 in zebrafish model.
Gessyka Rayana Silva Pereira, Gleidson Cardoso, Maria Luiza Kuhn Camargo, Michele Resende Machado, Mayara Macedo Barrozo, Juscelino Rodrigues, Gisele Augusto Rodrigues de Oliveira, Caio Monteiro, Christian Luz, Ricardo Neves Marreto, Stephânia Fleury Taveira   +10 more
wiley   +1 more source

Molecular Detection of Tick-Borne Bacterial Pathogens in Ticks and Rodents from the China–Vietnam Border

Veterinary Sciences
Ticks and tick-borne diseases constitute a crucial focus for the health of both humans and animals worldwide. Although numerous studies on tick-borne diseases have been conducted in China, reports on tick-borne pathogens in ticks and rodents from the ...
Hongbo Liu, Wenwei Xiao, Xinying Du, Jingzhuang Xue, Hui Wang, Qi Wang, Yule Wang, Huiqun Jia, Hongbin Song, Shaofu Qiu   +9 more
doaj   +1 more source

Camels as a Climate‐Resilient Linchpin for Sustainable Development in Global Drylands

Sustainable Development, EarlyView.
ABSTRACT Camels represent a significant, yet underutilized, asset for advancing integrated sustainable development in the world's expanding drylands. Previous reviews have examined camels' physiology, milk composition, or pastoral systems in isolation; this review examines their potential as a climate‐resilient linchpin for food systems by synthesizing
Ayana Angassa, Minyahel Tilahun, Solomon G. Tesfamichael   +2 more
wiley   +1 more source

‘Reservoir dogs’: The emerging zoonotic risk associated with European dog imports to the UK

Veterinary Record, EarlyView.
Abstract Background The movement of dogs from continental Europe to the UK poses a growing public health threat due to the associated risk of disease incursions. Current legislation is insufficient to address the risks and pre‐import control measures are focused only on rabies virus and the fox tapeworm Echinococcus multilocularis. Methods We conducted
Poppy Simonson, Tapan Bhattacharyya, Michael A. Miles   +2 more
wiley   +1 more source

Content analysis of TikTok videos about tick prevention methods for dogs and cats

Veterinary Record, EarlyView.
Abstract Background Social media is a major source of pet health information. On platforms such as TikTok, algorithm‐driven recommendations may expose users to health‐related content even without active searching. This study described tick prevention videos on TikTok.
Heidi Jim, Jongseo Kim, Ivana Blagojevic, Kelsey L. Spence   +3 more
wiley   +1 more source

Statewide surveillance of tick-borne pathogens in ticks collected in Delaware using novel multiplex PCR assays

International Journal for Parasitology: Parasites and Wildlife
Tick-borne pathogens are responsible for most vector-borne human diseases in the United States. With the growing recognition of tick-borne diseases and the expanding range of ticks, it is imperative to understand which pathogens, and in what prevalence ...
Michael H. Buoni, Ashley C. Kennedy, Virginia Hughes, Esther Biswas-Fiss   +3 more
doaj   +1 more source