Results 51 to 60 of about 53,067 (261)

Willingness and capacity of publicly-funded vector control programs in the USA to engage in tick management

Parasites & Vectors
Background The vast majority of vector-borne diseases in the USA are associated with mosquitoes or ticks. Mosquito control is often conducted as part of community programs run by publicly-funded entities.
James C. Burtis, Erik Foster, Rebecca J. Eisen, Lars Eisen   +3 more
doaj   +1 more source

Primary blood-hosts of mosquitoes are influenced by social and ecological conditions in a complex urban landscape

Parasites & Vectors, 2018
Background Temperate urban landscapes support persistent and growing populations of Culex and Aedes mosquito vectors. Large urban mosquito populations can represent a significant risk for transmission of emergent arboviral infection.
Heather Goodman, Andrea Egizi, Dina M. Fonseca, Paul T. Leisnham, Shannon L. LaDeau   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Fluazuron Baits in the Control of Amblyomma sculptum Tick: Efficacy and Pharmacokinetics Using Guinea Pigs as an Experimental Model

Pathogens
The tick Amblyomma sculptum is the vector of the bacterium Rickettsia rickettsii (which causes Brazilian Spotted Fever in humans). It can be found in domestic and wild animals, as well as humans. The objective of this work was to evaluate the efficacy of
Debora Azevedo Borges, Isabelle Vilela Bonfim, Clara Rodrigues Dutra, Ingrid Lins Raquel de Jesus, Rayane Monteiro, Rayane Christine Pereira de Assis, Fernando Rocha Miranda, Yara Peluso Cid, Fabio Barbour Scott   +8 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Control of tick-borne diseases

International Journal for Parasitology, 1987
Abstract The control of tick-borne protozoan diseases (babesiosis and theileriosis) depends on judicious integration of management, vector control, chemotherapy and immunization. The relative importance of each method will depend on the animal species involved as well as epidemiological and financial considerations.
openaire   +2 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

In vitro acaricidal activity of different ectoparasiticide classes against Amblyomma sculptum larvae

Revista Brasileira de Parasitologia Veterinária, 2020
Zoonoses are major causes of morbidity and mortality worldwide. Among them, Brazilian Spotted Fever (BSF) is an important one that occurs in some regions of South America and can be transmitted by the “star tick” Amblyomma sculptum.
Debora Azevedo Borges, Yara Peluso Cid, Barbara Rauta de Avelar, Thais Paes Ferreira, Diefrey Ribeiro Campos, Gabriela Carmelinda Martins dos Santos, Melina Cardilo Campos Alves, Fabio Barbour Scott   +7 more
doaj   +1 more source