Results 171 to 180 of about 633,129 (262)

Nanoscopic analysis of tight junction organization in in vitro blood-brain barrier models. [PDF]

Fluids Barriers CNS
Waldow A, Brachner A, Perriere N, Neuhaus W, Piontek J.   +4 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Editorial Expression of Concern: Role of TNF-α in lung tight junction alteration in mouse model of acute lung inflammation. [PDF]

Respir Res
Mazzon E, Cuzzocrea S.
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Tight Junction Defects in Aganglionic and Ganglionic Colon in Children With Hirschsprung Disease. [PDF]

Lab Invest
Rincon-Cruz L, Froehle L, Abhati S, Goldsmith J, Turner J, Nandivada P.   +5 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Tight junction proteins: Gatekeepers turned facilitators in the pathogenesis of gastric adenocarcinoma. [PDF]

World J Gastrointest Oncol
Selvam S, Vairappan B.
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Crypt-Level Tight Junction Remodeling Is Associated with Disease Course and Clinical Outcomes in Inflammatory Bowel Disease. [PDF]

Cells
Tsounis EP, Geramoutsou C, Pastras P, Aggeletopoulou I, Bosgana P, Lourida T, Diamantopoulou G, Ritsatou S, Koniaris E, Mantzaris GJ, Zolota V, Assimakopoulos SF, Bravou V, Thomopoulos K, Theocharis G, Triantos C.   +15 more
europepmc   +1 more source

Homomeric tight junction strand assembly of claudin proteins

Tight junctions, a form of cell junction, are utilized throughout the animal kingdom in one way or another. Tasked with facilitating a critical blockade between toxins and vital tissues while also allowing small crucial molecules to pass, the tight ...
Marsch, Patrick Matthew
core   +1 more source