Results 121 to 130 of about 8,941,456 (288)

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

Advanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang, Taolue Wang, Shilong Liu, Zicheng Zhang, Yibo Zhang, Fan Yang, Bo Yu, Shuaishuai Gao, Yu Chen, Lin Yang, Meng Zhou   +10 more
wiley   +1 more source

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

Advanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu   +9 more
wiley   +1 more source

An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli

Advanced Science, EarlyView.
An innervated human skin equivalent is integrated with high‐density microelectrode arrays to reveal how engineered free nerve ending–like structures translate touch and temperature into electrical codes. Mechanical indentation and thermal stimulation engage the engineered somatosensory circuitry and evoke distinct firing and waveform signatures ...
Daniele Bellantoni, Costantino Casale, Marika Sperduti, Nevio L. Tagliamonte, Giorgia Imparato, Loredana Zollo, Paolo A. Netti   +6 more
wiley   +1 more source

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

Optimization of Gabor Convolutional Networks Using the Taguchi Method and Their Application in Wood Defect Detection

Applied Sciences
Automated optical inspection (AOI) of wood surfaces is critical for ensuring product quality in the furniture and manufacturing industries; however, existing defect detection systems often struggle to generalize across complex grain patterns and diverse ...
Ming-Feng Yeh, Ching-Chuan Luo, Yu-Cheng Liu   +2 more
doaj   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Deep‐Learning‐Based Denoising for Improved Phase Precision in Electron Holography of Electromagnetic Fields in Nanoscale Materials

Advanced Science, EarlyView.
Low‐dose electron holography is limited by shot noise, which buries weak phase signals. HoloDenoiser, a physics‐informed network that works simultaneously in the spatial and frequency domains, locates and protects the holographic sideband while suppressing noise in the hologram.
Ye Luo, Luyang Wang, Zhiling Yu, Xiaowen Chen, Xiaoyu Wang, Ya‐Hui Jia, Thibaud Denneulin, Yu Han, Rafal E. Dunin‐Borkowski, Fengshan Zheng, Qi Liu   +10 more
wiley   +1 more source

Programmable Sequential 4D Actuation in Multistable Kirigami Metamaterials

Advanced Science, EarlyView.
This study presents a modular kirigami metamaterial framework enabling programmable multistability and sequential 4D actuation. By coupling geometry‐controlled multistability with material‐dependent recovery kinetics, spatiotemporal deformation can be precisely programmed.
Eui‐Hyun Kim, Minsung Kim, Hyunsik Yoon, Keun Park   +3 more
wiley   +1 more source

Real-time detection of macroplastic pollution in inland waters: development of a lightweight image recognition system

Frontiers in Environmental Science
Plastic pollution in freshwater ecosystems poses a growing environmental threat, yet the availability of efficient and scalable monitoring solutions remains limited.
Gergely Tikász, Miklós Gyalai-Korpos, Miklós Gyalai-Korpos, Gábor Fleit, Gábor Fleit, Sándor Baranya   +5 more
doaj   +1 more source