Results 61 to 70 of about 258,109 (284)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Correlation Between the Talar Tilt Angle and Hindfoot Varus in Medial Ankle OA

Foot & Ankle Orthopaedics, 2016
Category: Ankle Arthritis Introduction/Purpose: Radiographically medial ankle osteoarthritis shows different features according to talar tilt which is known to an important determining factor in low tibial osteotomy surgery.
Kyung-mu Kim MD, Hyun Seok Yim MD, Sung-Ha Hong BMed, Ki Sun Sung MD, PhD   +3 more
doaj   +1 more source

A Theoretical Optimum Tilt Angle Model for Solar Collectors from Keplerian Orbit

Energies, 2021
Solar energy has been extensively used in industry and everyday life. A more suitable solar collector orientation can increase its utilization. Many studies have explored the best orientation of the solar collector installation from the perspective of ...
Tong Liu, Li Liu, Yufang He, Mengfei Sun, Jian Liu, Guochang Xu   +5 more
doaj   +1 more source

Interferometric sensing of the tilt angle of a Gaussian beam

, 2020
We investigate interferometric techniques to estimate the deflection angle of an optical beam and compare them to the direct detection of the beam deflection. We show that quantum metrology methods lead to a unifying treatment for both single photons and
Aguilar, G. H., Davidovich, L., Filho, R. L. de Matos, Saldanha, P. L., Walborn, S. P.   +4 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Road Bank Angle Estimation for Three Wheel Tilting Vehicle Using Multi Model Estimator

MATEC Web of Conferences, 2018
In recent years, the need for micro-mobility, especially three-wheel vehicles, is increasing to address pollution and traffic congestion problems. With regard to the development of tilting vehicles, the precise tilt angle is important information in the ...
Jeong Kicheol, Choi Seibum
doaj   +1 more source

Advanced Diagnostics of Position Sensors for the Actuation Systems of High-Speed Tilting Trains [PDF]

, 2010
Trains tilting permits a train to travel at a high speed while maintaining an acceptable passenger ride quality with respect to the lateral acceleration, and the consequent lateral force, received by the passengers when the train travels on a curved ...
Jacazio, Giovanni, Risso, D., Sorli, Massimo, Tomassini, L.   +3 more
core  

Flow Analysis around Tilt-rotor Aircraft at Various Tilt Angles

Journal of the Korean Society of Visualization, 2011
Abstract. Tilt-rotor aircraft can be used in various fields because they have the capabilities of the ver-tical take-off and landing and the high-speed cruise flight. In the present study, the flow analysis of atilt-rotor aircraft is conducted at various tilt angles.
Su-Yean Kim, Jong-Wook Choi
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Measurements of Sunspot Group Tilt Angles Based on SOHO/MDI and SDO/HMI Magnetograms

The Astrophysical Journal
The tilt angle of sunspot groups plays a crucial role in solar dynamo models for the generation of the poloidal field, yet the statistical properties of the tilt angle are not fully comprehended.
Shu-Guang Zeng, Ao-Yu Zhao, Shuang Yi, Sheng Zheng, Xiang-Yun Zeng, Lin-Hua Deng, Yao Huang   +6 more
doaj   +1 more source