Results 231 to 240 of about 18,801,342 (289)

The immune checkpoint TIM-3/HMGB-1 axis in myocardial infarction. [PDF]

NPJ Cardiovasc Health
Yousif LI, Sijtema AG, Appels Y, Screever EM, van Blokland IV, Oelen R, Groot HE, Gergely TG, Kocsis M, Leszek P, Varga ZV, Aboumsallem JP, der Harst PV, Franke LH, van der Wijst MGP, de Boer RA, Lipšic E, Meijers WC.   +17 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

TIM-3 expression in tumor and stromal cells are associated with the prognosis in patients with epithelial ovarian cancer. [PDF]

Medicine (Baltimore)
Wu J, Zhang Y, Zhang H, Li Y, Jie Z, Kang S.   +5 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The concurrent silencing of Tim-3 and STAT-3 promotes tumor regression both in vitro and in ovo. [PDF]

BMC Cancer
Karami R, Khodayari S, Eshaghi F, Ebrahimi F, KhodaKarami A, Rashidi B, Nikdel M, Moshtagh Mehr H, Kazemi T, Jadidi F.   +9 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Effect of the TIM-3/Gal-9 signaling pathway on macrophage polarization in peri-implantitis. [PDF]

PLoS One
Cheng LJ, Dong SY, Ni XF, Mei L, He JG, Mamat A, Gong ZC.   +6 more
europepmc   +1 more source

Expression of TIM-3 and Gal-9 Immune Checkpoints in Chronic Lymphocytic Leukemia: The Potential Role of Interleukin-27. [PDF]

Curr Issues Mol Biol
Wędrowska E, Wandtke T, Ulaszewski B, Cichocka E, Dębski R, Kopiński P, Styczyński J, Przybylski G.   +7 more
europepmc   +1 more source

Targeting T cell exhaustion in colorectal cancer: emerging roles of LAG-3, TIM-3, and TIGIT signaling in overcoming immunotherapy resistance. [PDF]

Cell Commun Signal
Zamani P, Barootchi E, Firouzabadi A, Tonekaboni MS, Saleki K, Yazdanpanah N, Rezaei N.   +6 more
europepmc   +1 more source

Association of Tissue Expression of LAG-3 and TIM-3 with Clinical Features in Ovarian Cancer. [PDF]

Int J Mol Sci
Borzyszkowska D, Kozłowski M, Golara A, Piotrowska K, Brodowska A, Brodowski J, Bojar I, Kempinska-Podhorodecka A, Cymbaluk-Płoska A.   +8 more
europepmc   +1 more source