Results 221 to 230 of about 139,675 (244)

The regulation of TIM-3 transcription in T cells involves c-Jun binding but not CpG methylation at the TIM-3 promoter

Molecular Immunology, 2016
Tim-3 is an immunomodulatory protein that is expressed constitutively on monocytes but is induced in activated T cells. The mechanisms involved in the regulation of TIM-3 transcription are poorly understood. In the present study, we investigated whether methylation of the TIM-3 promoter is involved in regulatingTIM-3 transcription in T cells, and ...
Su Jin, Yun, Ka-Jung, Jun, Kuniharu, Komori, Mi Jin, Lee, Myung-Hee, Kwon, Yong-Joon, Chwae, Kyongmin, Kim, Ho-Joon, Shin, Sun, Park   +8 more
openaire   +2 more sources

Tim-3 Regulation of Cancer Immunity

2014
Chronic unrelenting immune responses can lead to immunopathology that can be fatal. Consequently, the immune system has evolved both molecular and cellular mechanisms that serve to contract active immune responses and restore immune homeostasis. Molecular mechanisms include the upregulation of inhibitory or immune checkpoint receptors on T cells post ...
Kaori Sakuishi, Ana C. Anderson
openaire   +1 more source

Discovery of TIM-3: Beyond a Th1 Regulator

The Journal of Immunology
Abstract This Pillars of Immunology article is a commentary on “Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease,” a pivotal article written by L. Monney, C. A. Sabatos, J. L. Gaglia, A. Ryu, H. Waldner, T. Chernova, S. Manning, E. A. Greenfield, A. J. Coyle, R. A. Sobel, G. J.
openaire   +2 more sources

Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity

Cancer Cell, 2021
Andrew Chow, Sara Schad, Michael D Green   +2 more
exaly  

Tim-3

2014
Kiera Clayton, Mario Ostrowski
openaire   +1 more source

The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

Immunity, 2021
Alvaro De Mingo Pulido, Kay Hänggi, Daiana P Celias   +2 more
exaly  

TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

Cancer Cell, 2023
Lucia Marrodan, Sandra Laternser, Jasper Van Der Lugt   +2 more
exaly  

TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer

Cancer Cell, 2018
Alvaro De Mingo Pulido, Alycia Gardner, Hatem Soliman   +2 more
exaly  

The costimulatory role of TIM molecules

Immunological Reviews, 2009
Rosemarie Dekruyff, Vijay K Kuchroo, Dale T Umetsu   +2 more
exaly  

A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9

Biochemical and Biophysical Research Communications, 2006
Joseph V Bonventre, Gerd Walz, E Wolfgang Kuehn   +2 more
exaly