Results 71 to 80 of about 17,630,315 (317)

Analysis of Tim-3 as a therapeutic target in prostate cancer

Tumor Biology, 2017
Tim-3 (T-cell immunoglobulin domain and mucin domain–containing molecule 3) is a newly discovered immunomodulatory protein, which plays an important role in immunity regulation. Recent evidence suggests that Tim-3 is differentially regulated in a variety
Yongrui Piao, Xuanshun Jin
doaj   +1 more source

Tim-3 protects against cisplatin nephrotoxicity by inhibiting NF-κB-mediated inflammation

Cell Death Discovery, 2023
The impact of Tim-3 (T cell immunoglobulin and mucin domain-containing protein 3) on cisplatin-induced acute kidney injury was investigated in this study.
Peiyao Li, Xuemiao Li, Wenbin Wu, Mengjia Hou, Guanyi Yin, Zhonghang Wang, Ziyu Du, Yuanfang Ma, Yinxiang Wei, Qiang Lou   +9 more
semanticscholar   +1 more source

Motivation to shape the future of education with Artificial Intelligence: An international comparison between Switzerland and China

Computers and Education Open
As digital technologies and Artificial Intelligence (AI) continue to reshape educational environments, understanding the motivations of student teachers is critical to developing effective teacher education programmes.
Judit Martínez-Moreno, Xinyan Zhou, Dominik Petko, Thomas K.F. Chiu   +3 more
doaj   +1 more source

The Role of Tim-3 on dNK Cells Dysfunction During Abnormal Pregnancy With Toxoplasma gondii Infection

Frontiers in Cellular and Infection Microbiology, 2021
Vertical transmission of Toxoplasma gondii (T. gondii) infection during gestation can result in severe complications such as abortion, congenital malformation, fetal teratogenesis, etc.
Teng Li, Lijun Cui, Xiaoyan Xu, Haixia Zhang, Yuzhu Jiang, Liqin Ren, Chunyan Yang, Xianbing Liu, Xuemei Hu   +8 more
doaj   +1 more source

T Cell Immunoglobulin and Mucin Domain 3 (TIM-3) in Cutaneous Melanoma: A Narrative Review

Cancers, 2023
Simple Summary T cell immunoglobulin and mucin domain 3 (TIM-3) is an inhibitory immunocheckpoint expressed on cytotoxic CD8+ T lymphocytes, NK cells, and myeloid lineage cells in addition to Th1 lymphocytes.
Gerardo Cazzato, E. Cascardi, A. Colagrande, T. Lettini, A. Filosa, F. Arezzo, C. Lupo, Nadia Casatta, V. Loizzi, C. Pellegrini, M. Fargnoli, Eugenio Maiorano, G. Cicco, R. Tamma, G. Ingravallo   +14 more
semanticscholar   +1 more source

Association of TIM-3 checkpoint receptor expression on T cells with treatment-free remission in chronic myeloid leukemia

Blood Advances, 2023
Key Points • TIM-3 is the only immune-checkpoint receptor consistently overexpressed in patients with CML who relapse after TKI cessation.• Overexpression of TIM-3 provides a rationale to test TIM-3 inhibitors to modify treatment-free remission outcomes.
Yazad D. Irani, C. Kok, J. Clarson, Naranie Shanmuganathan, S. Branford, D. Yeung, D. Ross, T. Hughes, A. Yong   +8 more
semanticscholar   +1 more source

Establishment of novel anti-TIM-3 antibodies interfering with its binding to ligands

Heliyon
The T cell immunoglobulin and mucin-domain containing-3 (TIM-3) receptor has gained significant attention as a promising target for cancer immunotherapy.
Zhuohong Yan, Teng Ma, Xiaojue Wang, Ling Yi, Panjian Wei, Hongtao Zhang, Jinghui Wang   +6 more
doaj   +1 more source

The inhibitory receptor Tim-3 fails to suppress IFN-γ production via the NFAT pathway in NK-cell, unlike that in CD4+ T cells

BMC Immunology, 2021
Background T cell immunoglobulin and mucin domain-containing-3 (Tim-3) is a negative regulator expressed on T cells, and is also expressed on natural killer (NK) cells.
Xiaowen Yu, Bin Lang, Xi Chen, Yao Tian, Shi Qian, Zining Zhang, Yajing Fu, Junjie Xu, Xiaoxu Han, Haibo Ding, Yongjun Jiang   +10 more
doaj   +1 more source

Immune Checkpoint Profiling in Humanized Breast Cancer Mice Revealed Cell-Specific LAG-3/PD-1/TIM-3 Co-Expression and Elevated PD-1/TIM-3 Secretion

Cancers, 2023
Simple Summary Different immunotherapies have been approved for the treatment of a multiplicity of cancers. However, a large proportion of patients do not respond or develop resistance, meaning that specified treatment combinations are required to ...
C. Bruss, K. Kellner, V. Albert, James A. Hutchinson, S. Seitz, O. Ortmann, G. Brockhoff, A. Wege   +7 more
semanticscholar   +1 more source

What Do Forbidden Light-ray Fields Look Like? [PDF]

, 2014
Ray-optically, optical components change a light-ray field on a surface immediately in front of the component into a different light-ray field on a surface behind the component.
Courtial, Johannes, Oxburgh, Stephen, Stockman, Paul, Tyc, Tomáš   +3 more
core   +1 more source