Results 71 to 80 of about 971,002 (215)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Analyzing Systemic Risk Spillover Networks Through a Time-Frequency Approach

Mathematics
This paper investigates the spillover effects and transmission networks of systemic risk within China’s national economic sectors under extreme conditions from both time and frequency domain perspectives, building upon the spillover index methodology and
Liping Zheng, Ziwei Liang, Jiaoting Yi, Yuhan Zhu   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Research on Coal Gangue Recognition Based on Multi-source Time-Frequency Domain Feature Fusion. [PDF]

ACS Omega, 2023
Zhang Y, Yang Y, Zeng Q.
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

COMPARISON BETWEEN TWO DIMENSIONALITY REDUCTION METHODS IN TIME SERIES COMPARACIÓN ENTRE DOS MÉTODOS DE REDUCCIÓN DE DIMENSIONALIDAD EN SERIES DE TIEMPO

Revista Colombiana de Estadística, 2009
Two methods of dimensionality reduction of multivariate stationary time series are analyzed: Peña-Box’s methodology in the time domain and Brillinger’s methodology in the frequency domain.
Zhang Hanwen
doaj  

Evaluating the indicators of a heart rate variability analysis in dogs using Poincaré plots

Veterinární Medicína
Heart rate variability analyses using Poincaré plots can be useful for evaluating the autonomic nervous system function. However, the interpretation of the quantitative indicators of Poincaré plots remains controversial.
T Kimura, S Shimamura, H Sakaya, T Hayashi, A Umemoto, K Sakai, M Yamasaki, T Hasegawa, T Shimada   +8 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Comparación entre dos métodos de reducción de dimensionalidad en series de tiempo

Revista Colombiana de Estadística, 2009
En este trabajo se analizan dos métodos de reducción de dimensionalidad en series de tiempo multivariadas estacionarias: el método de Peña y Box, basado en el dominio del tiempo, y el método de Brillinger, basado en el dominio de las frecuencias.
HANWEN ZHANG
doaj  

Global energy markets connectedness: evidence from time-frequency domain. [PDF]

Environ Sci Pollut Res Int, 2023
Rehman MU, Naeem MA, Ahmad N, Vo XV.
europepmc   +1 more source