Results 91 to 100 of about 2,427,094 (264)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Discharge propagation analysis of regional and basin floods in the middle and lower reaches of the Yangtze River

Shui kexue jinzhan
Flood propagation is pivotal to flood control security，affecting channel erosion-deposition processes，fluvial regime evolution，and river-lake interactions. Analyzing the composition and downstream variability of typical floods in the frequency domain has
Hongyang ZHANG, Chunhong HU, Man ZHOU, Yu GAO, Jianzhao GUAN   +4 more
doaj   +1 more source

Impaired circadian heart rate variability in Parkinson's disease: a time-domain analysis in ambulatory setting. [PDF]

BMC Neurol, 2020
Arnao V, Cinturino A, Mastrilli S, Buttà C, Maida C, Tuttolomondo A, Aridon P, D'Amelio M.   +7 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Enhanced DC Series Arc-Fault Detection in LVDC Systems With Capacitor-Assisted Impedance Shaping

IEEE Access
A DC grid can achieve high power conversion efficiency by reducing conversion stages between DC energy resources and loads. However, as system complexity increases, DC distribution systems face series arc faults due to damaged power cables and loose ...
Chun-Sung Kim, Hyun-Jun Choi, Taesic Kim, Mina Kim, Wan Kim, Hwa-Pyeong Park   +5 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

New Method for Pore-Throat Parameter Characterization of Tight Sandstone Reservoirs Based on Nuclear Magnetic Resonance Logging

Cejing jishu
To address the problems of limited prediction accuracy and high inversion uncertainty of low signal-to-noise ratio echo data when traditional nuclear magnetic resonance (NMR) logging T2 spectra are converted into pseudo-capillary pressure curves for ...
JIN Guowen, MA Chao, ZHANG Qiance, XIE Ranhong, TIAN Zhi, MENG Huan, LI Hua   +6 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

IMU-Based Time-Domain Fault Diagnosis of BLDC Motors Using an End-to-End 1D-CNN

Modelling
Reliable fault detection in brushless DC motors is challenging owing to environmental complexity and high equipment costs. To address these challenges, we propose an effective and cost-effective approach using an optimized end-to-end one-dimensional ...
Ke Hao Wang, Hwi Gyu Lee, Seon Min Yoo, In Soo Lee   +3 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source