Results 111 to 120 of about 5,394,829 (294)

Noise Propagation and Mitigation in High-Rise Buildings Under Urban Traffic Impact

Buildings
Urban traffic noise poses escalating environmental challenges in rapidly urbanizing regions with high-density buildings, yet systematic investigations into its spatiotemporal characteristics remain relatively scarce.
Shifeng Wu, Yanling Huang, Qingchun Chen, Guangrui Yang   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Enhanced DC Series Arc-Fault Detection in LVDC Systems With Capacitor-Assisted Impedance Shaping

IEEE Access
A DC grid can achieve high power conversion efficiency by reducing conversion stages between DC energy resources and loads. However, as system complexity increases, DC distribution systems face series arc faults due to damaged power cables and loose ...
Chun-Sung Kim, Hyun-Jun Choi, Taesic Kim, Mina Kim, Wan Kim, Hwa-Pyeong Park   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

New Method for Pore-Throat Parameter Characterization of Tight Sandstone Reservoirs Based on Nuclear Magnetic Resonance Logging

Cejing jishu
To address the problems of limited prediction accuracy and high inversion uncertainty of low signal-to-noise ratio echo data when traditional nuclear magnetic resonance (NMR) logging T2 spectra are converted into pseudo-capillary pressure curves for ...
JIN Guowen, MA Chao, ZHANG Qiance, XIE Ranhong, TIAN Zhi, MENG Huan, LI Hua   +6 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Discharge propagation analysis of regional and basin floods in the middle and lower reaches of the Yangtze River

Shui kexue jinzhan
Flood propagation is pivotal to flood control security，affecting channel erosion-deposition processes，fluvial regime evolution，and river-lake interactions. Analyzing the composition and downstream variability of typical floods in the frequency domain has
Hongyang ZHANG, Chunhong HU, Man ZHOU, Yu GAO, Jianzhao GUAN   +4 more
doaj   +1 more source

Comprehensive bearing condition monitoring algorithm for incipient fault detection using acoustic emission [PDF]

Jurnal Tribologi, 2014
The bearing reliability plays major role in obtaining the desired performance of any machine. A continuous condition monitoring of machine is required in certain applications where failure of machine leads to loss of production, human safety and ...
Amit R. Bhende, Gajanan K. Awari, Sachin P. Untawale   +2 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source