Results 131 to 140 of about 16,901 (243)

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

open access: yesAngewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann   +10 more
wiley   +1 more source

Harnessing plant‐based platform for low‐cost cellulosic sugar recovery from bioenergy crops

open access: yesBiofuels, Bioproducts and Biorefining, EarlyView.
Abstract The price of pure cellulase enzyme for the recovery of fermentable cellulosic sugars is one of the major challenges that limit the commercialization of second‐generation biofuels and bio‐based products. This work shows a means to greatly reduce the cost of cellulases. The abundant capacity of plants to synthesize and hyperaccumulate transgenic
Shraddha Maitra   +4 more
wiley   +1 more source

Advanced glucose control strategies leveraging Raman spectroscopy for optimized mammalian cell culture manufacturing

open access: yesBiotechnology Progress, EarlyView.
Abstract Maintaining consistent quality in the manufacturing of biotherapeutic proteins in mammalian cell culture is challenging, with unplanned deviations causing inconsistencies and potential batch failure. Current methods for monitoring and controlling critical process parameters (CPPs) rely on slow, labor‐intensive offline analyses.
Matthew Banner   +12 more
wiley   +1 more source

Sonic Heritage and Acoustic Profiling of the Gendang Kecapi: A Bamboo-Based Instrument from Kelantan, Malaysia

open access: yesBioResources
This study considered the ‘Gendang Kecapi’ (GK) musical instrument, the sounds of which were recorded in an anechoic chamber. The Fast Fourier Transform (FFT) data was obtained using a Picoscope oscilloscope.
Aaliyawani Ezzerin Sinin   +5 more
doaj  

Evaluating Trans-Fatty Acids Labelling in Packaged Foods Sold in Brazil Before and After National Policy Changes. [PDF]

open access: yesJ Hum Nutr Diet
Barros BV   +9 more
europepmc   +1 more source

External Acoustic Meatus Approach for Ultrasonographic Evaluation of the Temporomandibular Joint: An Anatomical Validation and Proof‐of‐Concept Study

open access: yesClinical Anatomy, EarlyView.
ABSTRACT Temporomandibular disorders (TMD) represent a public health problem, affecting 31% of adults and the elderly and 11% of children and adolescents. Interest is growing in using ultrasound to evaluate the temporomandibular joint (TMJ). However, researchers need to standardize a reliable method.
Rossella Alberti   +10 more
wiley   +1 more source

Comparative Evaluation of Starch and Protein Characteristics in Ancient Wheat Species

open access: yesCereal Chemistry, EarlyView.
ABSTRACT Background and Objectives Driven by increasing consumer demand for nutrient‐dense and more sustainable food options, ancient wheat species present a promising opportunity due to their environmental adaptability and perceived health benefits. Therefore, this study aims to evaluate the starch and protein characteristics of ancient wheat species,
Sathsara Deyalage   +3 more
wiley   +1 more source

The Hasapi of the Batak Toba from Sumatra Indonesia

open access: yesBioResources
The hasapi of the Batak Toba from Sumatra, Indonesia is a plucked bowl-lute chordophone. Hasapi is a fretless chordophone with two strings. The tuning for the hasapi used in this study is based on the transcription of the song ‘Horbo Paung’ played in F ...
Aaliyawani Ezzerin Sinin   +4 more
doaj  

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