Results 101 to 110 of about 1,433,403 (294)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

"Causes, Consequences and Dynamics of 'Complex' Distributions of Technological Activities: The Case of Prolific Inventors" [PDF]

We provide a framework for understanding the causes and consequences of the observed shapes of the distributions of individual inventors' productivities.
Christian Le Bas, William Latham
core  

Empirical distributions of Chinese stock returns at different microscopic timescales

, 2007
We study the distributions of event-time returns and clock-time returns at different microscopic timescales using ultra-high-frequency data extracted from the limit-order books of 23 stocks traded in the Chinese stock market in 2003.
Bertram, Biais, Black, Blattberg, Bouchaud, Brada, Castaing, Castaing, Castaing, Castaing, Clark, Coronel-Brizio, Fama, Fama, Gao-Feng Gu, Ghashghaie, Gopikrishnan, Gopikrishnan, Griffiths, Gu, Hall, Kiyono, Laherrere, Laurent, Lee, Makowiec, Malevergne, Malevergne, Malevergne, Mandelbrot, Mandelbrot, Mandelbrot, Mandelbrot, Mandelbrot, Mandelbrot, Mantegna, Mantegna, Matia, Osborne, Osborne, Pan, Pan, Plerou, Silva, Sornette, Wang, Wei Chen, Wei-Xing Zhou, Yan, Zhang   +49 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Wavelet Transform in Vibration Analysis for Mechanical Fault Diagnosis

Shock and Vibration, 1996
The wavelet transform is introduced to indicate short-time fault effects in associated vibration signals. The time-frequency and time-scale representations are unified in a general form of a three-dimensional wavelet transform, from which two-dimensional
W.J. Wang
doaj   +1 more source

On accumulated Cohen's class distributions and mixed-state localization operators

, 2018
Recently we introduced mixed-state localization operators associated to a density operator and a (compact) domain in phase space. We continue the investigations of their eigenvalues and eigenvectors.
Luef, Franz, Skrettingland, Eirik
core  

Lifetime of the superconductive state in short and long Josephson junctions

, 2008
We study the transient statistical properties of short and long Josephson junctions under the influence of thermal and correlated fluctuations. In particular, we investigate the lifetime of the superconductive metastable state finding the presence of ...
Augello, Giuseppe, Pankratov, Andrey L., Spagnolo, Bernardo, Valenti, Davide   +3 more
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source