Results 71 to 80 of about 2,252,514 (265)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Time History Analysis of Frame Structure Systems by State-space Representation Method
Polytechnic Journal, 2020 This paper develops the state-space representation (SSR) in the field of seismic analysis of the building structures. Dynamic analysis of multi-degree-of-freedom structures involves the solution of second-order linear differential equations which they ...
Barham H. Ali +2 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Conceptualizing Time Preference: A Life-History Analysis
Evolutionary Psychology, 2014 Life-history theory (LHT) has drawn upon the concept of “time preference” as a psychological mechanism for the development of fast and slow strategies. However, the conceptual and empirical nature of this mechanism is ill-defined.
Lee T. Copping +2 more
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Damping of Glass Structures and Components
Challenging Glass Conference Proceedings, 2016 In this paper, the dynamic properties of a glass structures and glass components will be discussed. A short introduction to dynamic load will be presented as well as the basic principles of calculus used behind the widely understood finite element ...
Peter Lenk, Graham Coult
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Time-History Analysis of Composite Materials with Rectangular Microstructure under Shear Actions. [PDF]
Materials (Basel), 2021 Colatosti M, Fantuzzi N, Trovalusci P.
europepmc +1 more source
Nonlinear Time History Analysis for Seismic Effects on Reinforced Concrete Building
Nigerian Journal of Technological Development, 2022 A typical Reinforced Concrete (RC) building frame comprising of RC columns and connecting beams that participates in resisting the earthquake forces.
A. Hasan +3 more
doaj +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source