Results 191 to 200 of about 124,888,785 (314)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

THE CHALLENGES OF TIME-BASED ARRIVAL MANAGEMENT

open access: yes, 2010
DLR’s arrival manager 4D-CARMA (4 Dimensional Co-operative ARrival MAnager) supports time-based arrival management.
Helmke, Hartmut
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Clips: a capacity and lead time integrated procedure for scheduling. [PDF]

open access: yes
We propose a general procedure to address real life job shop scheduling problems. The shop typically produces a variety of products, each with its own arrival stream, its own route through the shop and a given customer due date.
Lambrecht, Marc   +2 more
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Staffing service centers under arrival-rate uncertainty

open access: yes, 2012
textWe consider the problem of staffing large-scale service centers with multiple customer classes and agent types operating under quality-of-service (QoS) constraints.
Zan, Jing, 1983-
core  

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