Results 171 to 180 of about 2,373,079 (328)

pH and temperature dependent relaxation dynamics of Hoechst-33258: a time resolved fluorescence study [PDF]

, 2010
N. Barooah, Jyotirmayee Mohanty, Haridas Pal, Sisir K. Sarkar, Tulsi Mukherjee, Achikanath C. Bhasikuttan   +5 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Time-resolved X-ray diffraction studies of structural transitions in organic polymers using synchrotron radiation

, 1994
W. Fuller, A. Mahendrasingam, A. Jaber, C. Martin, Darren J. Hughes, R. J. Oldman, D.J. Blundell, D. MacKerron   +7 more
openalex   +2 more sources

Ultrafast pump-probe and time-resolved fluorescence anisotropy study of the intramolecular interaction of branched styryl derivatives based on 1,3,5-triazine [PDF]

, 2019
Yaochuan Wang, Yizhuo Wang, Guiqiu Wang, Dajun Liu   +3 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Unraveling Electron Dynamics in p-type Indium Phosphide (100): A Time-Resolved Two-Photon Photoemission Study [PDF]

Jonathan Diederich, Jennifer Velasquez Rojas, Mohammad Amin Zare Pour, Isaac Azahel Ruiz Alvarado, Agnieszka Paszuk, Rachele Sciotto, Christian Höhn, Klaus Schwarzburg, David Ostheimer, Rainer Eichberger, W. G. Schmidt, Thomas Hannappel, Roel van de Krol, Dennis Friedrich   +13 more
openalex   +1 more source

Erratum: Hot luminescence intrans-polyacetylene: A picosecond time-resolved study [PDF]

, 1984
John R. Andrews, T. E. Orlowski, Harry W. Gibson, Michael L. Slade, Wayne H. Knox, Bruce P. Wittmershaus   +5 more
openalex   +1 more source

Time-resolved studies of ultrafast wavepacket dynamics in hydrogen molecules [PDF]

, 2010
Bryan, W. A., Calvert, C. R., Newell, W. R., Williams, I. D.   +3 more
core   +1 more source