Results 71 to 80 of about 305,083 (282)

A Taxonomy for Management and Optimization of Multiple Resources in Edge Computing

, 2018
Edge computing is promoted to meet increasing performance needs of data-driven services using computational and storage resources close to the end devices, at the edge of the current network.
Nadjm-Tehrani, Simin, Toczé, Klervie
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Research on Time Synchronization of Train Communication Based on Time-sensitive Networking

Chengshi guidao jiaotong yanjiu
Objective The millisecond-level precision of NTP (network time protocol) in train communication networks has increasingly failed to meet the requirements of high traffic and deterministic transmission.
ZHANG Junxian, LIANG Rujun, HUANG Tao, ZHANG Wenyi, XU Long, XIONG Wei, ZHU Hailong, PENG Kailai   +7 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Efficient Robust Schedules (ERS) for Time-Aware Shaping in Time-Sensitive Networking

IEEE Open Journal of the Communications Society
Time-Sensitive Networking (TSN) extends Ethernet bridging with features for deterministic transmission. Periodic streams may be scheduled such that their frames hardly interfere in bridges.
Thomas Stuber, Lukas Osswald, Michael Menth   +2 more
doaj   +1 more source

Precise Clock Synchronization in High Performance Wireless Communication for Time Sensitive Networking

IEEE Access, 2018
In this paper, an enhanced precision time protocol (PTP) to enable precise clock synchronization between the nodes within an industrial wireless sensor network deployed for critical control and automation applications is proposed. As it will be shown, by
Deep Shrestha, Zhibo Pang, Dacfey Dzung
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Configuration of multi‐shaper Time‐Sensitive Networking for industrial applications

IET Networks
IEEE 802.1 Time‐Sensitive Networking (TSN) has proposed several shapers, for example, time‐aware shaper (TAS, 802.1Qbv), asynchronous traffic shaping (ATS, 802.1Qcr), credit‐based shaper (CBS, 802.1Qav), and cyclic queuing and forwarding (CQF, 802.1Qch).
Paul Pop, Konstantinos Alexandris, Tongtong Wang   +2 more
doaj   +1 more source

The Boston Girls Sports & Physical Activity Project: Final Report to the Barr Foundation [PDF]

, 2007
The main goal of the three-year Boston Girls' Sports & Physical Activity Project (BGSPAP) was to create an integrated and sustainable network of community-based programs that use sports and physical activity to favorably influence the physical ...

core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source