Results 51 to 60 of about 424,943 (312)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Data Representation Based on Interval-Sets for Anomaly Detection in Time Series

IEEE Access, 2018
Anomaly detection in time series is a popular topic focusing on a variety of applications, which achieves a wealth of results. However, there are many cases of missing anomaly and increased false alarm in most of the existing works.
Huorong Ren, Xixi Li, Zhiwu Li, Witold Pedrycz   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Spatio-Temporal Consistency for Multivariate Time-Series Representation Learning

IEEE Access
Label sparsity in multivariate time series (MTS) makes using label information for practical applications challenging. Thus, unsupervised representation learning methods have gained attention to learn effective representations suitable for various MTS ...
Sangho Lee, Wonjoon Kim, Youngdoo Son
doaj   +1 more source

Multivariate Extreme Learning Machine Based AutoEncoder for Electricity Consumption Series Clustering

IEEE Access, 2021
Multivariate electricity consumption series clustering can reflect the trend of power consumption changes in the past time period, which can provide reliable guidance for electricity production.
Kaihong Zheng, Jingfeng Yang, Qihang Gong, Shangli Zhou, Lukun Zeng, Sheng Li   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Simulating Temporally and Spatially Correlated Wind Speed Time Series by Spectral Representation Method

Complex System Modeling and Simulation, 2023
In this paper, it aims to model wind speed time series at multiple sites. The five-parameter Johnson distribution is deployed to relate the wind speed at each site to a Gaussian time series, and the resultant m-dimensional Gaussian stochastic vector ...
Qing Xiao, Lianghong Wu, Xiaowen Wu, Matthias Rätsch   +3 more
doaj   +1 more source

A Multiresolution Symbolic Representation of Time Series [PDF]

21st International Conference on Data Engineering (ICDE'05), 2005
Efficiently and accurately searching for similarities among time series and discovering interesting patterns is an important and non-trivial problem. In this paper, we introduce a new representation of time series, the Multiresolution Vector Quantized (MVQ) approximation, along with a new distance function.
Megalooikonomou, Vasileios, Wang, Qiang, Li, Guo, Faloutsos, Christos   +3 more
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Robust Time Series Contrastive Representation Learning via Explicit Seasonal-Trend Disentanglement

IEEE Access
We address universal self-supervised representation learning for time series under label scarcity and distribution shifts. A key challenge is that prevalent encode-then-decompose pipelines only implicitly separate seasonal and trend signals, which mixes ...
Fuyu Li, Bo Jin
doaj   +1 more source