Results 71 to 80 of about 679,272 (219)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Event-triggered control of nonlinear systems with input saturation and time-varying control gain

Automatika
In this paper, an event-triggered adaptive control law is proposed by backstepping for a class of nonlinear systems with unknown saturation input. It also considers uncertain constant parameters and unknown time-varying input gains in the system.
Jianping Cai, Jianghong Zhu, Dong Guo, Congli Mei, Jiamin Cui   +4 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Membership-function-dependent control of fuzzy systems with time-varying delays

四川大学学报. 自然科学版, 2019
This paper investigates the stability analysis and stabilization for T-S fuzzy systems with time-varying delays. Firstly, an augmented Lyapunov-Krasovskii functional is constructed, delay-dependent stability criteria in terms of linear matrix ...
zhoukun, QI Shu-nan, LI Jing, JIN Liu-Qian, CAI Ji-rong, HUANG Tian-nin   +5 more
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Time-Varying LQR Control with Matrix Smoothing for Continuous-Time Switched Systems Under Time-Dependent Switching

Applied Sciences
This paper addresses the analysis and control of continuous-time linear switched systems within the linear time-varying (LTV) framework. A correspondence between switched and LTV system representations is first established, enabling the use of LTV tools ...
Kamil Borawski, Krzysztof Rogowski
doaj   +1 more source

Controllability of nonlinear stochastic systems with multiple time-varying delays in control

International Journal of Applied Mathematics and Computer Science, 2015
This paper is concerned with the problem of controllability of semi-linear stochastic systems with time varying multiple delays in control in finite dimensional spaces.
Karthikeyan Shanmugasundaram, Balachandran Krishnan, Sathya Murugesan   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source