Results 61 to 70 of about 439,715 (267)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The Impact of Tourism Activities on Carbon Emissions: Evidence Using a Time-Varying Parameter Vector Autoregression Model

İktisat Politikası Araştırmaları Dergisi
This article examines the impact of tourism activities, economic growth, and energy demand on environmental degradation in Turkey using Primiceri’s (2005) time-varying parameter structural vector autoregression model for the period 1991:Q1 to 2020:Q1 ...
A. Nazif Çatık, Esra Ballı, Coşkun Akdeniz, Cihan Çobanoğlu, Mohamad Husam Helmi   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Almost periodic solutions of distributed parameter biochemical systems with time delay and time varying input

Electronic Journal of Differential Equations, 2013
In this article we study the existence of almost periodic solutions for distributed parameters biochemical system, with time delay when the input $S_{m in}$ is time dependent.
Abdou K. Drame, Mangala R. Kothari, Peter R. Wolenski   +2 more
doaj  

Bianchi Type-V Bulk Viscous Cosmic String in f(R,T) Gravity with Time Varying Deceleration Parameter

Advances in High Energy Physics, 2015
We study the Bianchi type-V string cosmological model with bulk viscosity in f(R,T) theory of gravity by considering a special form and linearly varying deceleration parameter.
Bïnaya K. Bishi, K. L. Mahanta
doaj   +1 more source

Finite-Time Asynchronous Stabilization for Nonlinear Hidden Markov Jump Systems with Parameter Varying in Continuous-Time Case

Complexity, 2020
The finite-time asynchronous stabilization problem has received great attention because of the wide application of actual engineering. In this paper, we consider the problem of finite-time asynchronous stabilization for nonlinear hidden Markov jump ...
Lianjun Xiao, Xiaofeng Wang, Lingling Gao   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A Bayesian model calibration framework for stochastic compartmental models with both time-varying and time-invariant parameters

Infectious Disease Modelling
We consider state and parameter estimation for compartmental models having both time-varying and time-invariant parameters. In this manuscript, we first detail a general Bayesian computational framework as a continuation of our previous work ...
Brandon Robinson, Philippe Bisaillon, Jodi D. Edwards, Tetyana Kendzerska, Mohammad Khalil, Dominique Poirel, Abhijit Sarkar   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An integrated framework for non-stationary hydrological drought assessment using time-varying parameter standardized streamflow index and time-varying threshold level method

Journal of Hydrology: Regional Studies
Study region: Weihe River basin (WRB) in northern China. Study focus: In a changing environment, traditional drought assessment methods may not be applicable when assumptions of stationarity are violated. Accordingly, this study proposes a framework that
Menghao Wang, Shanhu Jiang, Liliang Ren, Junzeng Xu, Shanshui Yuan, Chong-Yu Xu   +5 more
doaj   +1 more source