Results 111 to 120 of about 23,327,589 (260)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A nyquist criterion for time-varying periodic systems, with application to a hydraulic test bench [PDF]

, 2002
In this paper, stability results dedicated to sampled periodic systems are applied to a mechanical system whose stiffness exhibits quick variations: a hydraulic test bench used to achieve mechanical test on complex structures.
Oustaloup, Alain, Pommier-Budinger, Valérie, Sabatier, Jocelyn, Garcia Iturricha, Aitor   +3 more
core  

Numerical Study on Identification of Time Varying Parameters of Vibration Systems

Shock and Vibration, 1997
An on-line least squares algorithm has previously been successfully applied to linear vibration systems in order to identify time varying parameters. In this article the limitations of the approach and the factors affecting the identification are further
Yanchun Liang, Qiang Zhen, Zaishen Wang
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Controller Design for Continuous-Time Linear Control Systems with Time-Varying Delay

Mathematics
This paper addresses the controller design problem for linear systems with time-varying delays. By constructing a novel Lyapunov–Krasovskii functional incorporating delay-partitioning techniques, we establish delay-dependent stability criteria for the ...
Hongli Yang, Lijuan Yang, Ivan Ganchev Ivanov   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

L_p stability of time-varying linear feedback systems

, 1972
In this note, we consider the input-output stability of feedback systems whose forward element is linear and time varying and whose feedback element is a memoryless gain multiplier with a gain that is absolutely integrable as a function of time ...
Vidyasagar, M.
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Hankel norm of polytopic systems with time-varying delay

, 2008
This paper addresses the Hankel norm of polytopic systems with time-varying delay. Delay-dependent sufficient conditions are presented such that the polytopic system is stable and the Hankel norm of the polytopic system is less than a prescribed scalar ...
Wang QY(王清阳), Qing Wang
core