Results 101 to 110 of about 3,428,293 (288)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
IEEE Access, 2018 This work was supported in part by the National Key R&D Program of China under Grant 2017YFB1002505, in part by the National Natural Science Foundation of China under Grant 61603142 and Grant 61633010, in part by the Guangdong Foundation for ...
Zhijun Zhang +5 more
doaj +1 more source
Smoothing for time-varying systems using measurements containing colored noise [PDF]
Optimal smoother derived for linear time-varying systems using measurements containing colored noise by means of calculus of ...
Bryson, A. E., Jr., Mehra, R. K.
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Policy iteration for H∞ control of polynomial time‐varying systems
IET Control Theory & ApplicationsThis paper studies the H∞ control problem for polynomial time‐varying systems. The H∞ control problem has been much less investigated for time‐varying systems in comparison to the time‐invariant systems.
Sajjad Pakkhesal, Saeed Shamaghdari
doaj +1 more source
IET Cyber-Physical Systems, 2017 Uncertain dynamics in communication network, including random delays and packet losses make it difficult to guarantee stability of cyber-physical systems (CPSs).
Shanshan Bi, Maciej Zawodniok
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Distributed finite-time information discovery-based secondary restoration for islanded microgrids
IET Smart Grid, 2019 A new finite-time secondary voltage and frequency restoration scheme for an islanded microgrid (MG) is proposed in this study. All distributed generators (DGs) do not have access to the voltage and frequency reference value which makes their control more
Sonam Shrivastava, Bidyadhar Subudhi
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source